Body size, physical activity, and Hodgkin's disease risk

体型、体力活动和霍奇金病风险

• 批准号: 6838960
• 负责人: SALLY L GLASER
• 金额: $ 6.97万
• 依托单位: CANCER PREVENTION INSTIT OF CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6838960
• 关键词: Hodgkin' s disease; adult human (21+); body composition; body height; body physical activity; body physical characteristic; body weight; cancer risk; clinical research; comorbidity; disease /disorder proneness /risk; female; immune response; immunocytochemistry; in situ hybridization; questionnaires; socioeconomics

DESCRIPTION (provided by applicant): Hodgkin's disease (HD) is a common cancer of young adults for which etiology is far from established, and few novel leads have been identified. Scattered reports have linked HD risk with taller height, heavier weight and less physical activity. Body size and physical activity are believed to affect immune function and hormone regulation, both postulated as relevant to HD etiology, but their impact on HD risk has had very little consideration, especially in women. We propose to examine risk for HD in women associated with body size and physical activity over the life-span to test the hypotheses that: 1) Height in adulthood and relative height in childhood are associated with increased HD risk. 2) Birth weight and weight adjusted for height (body mass index) throughout adulthood are associated with HD risk. 3) Frequency of strenuous physical activity in adolescence and through adulthood is associated with HD risk. We will address these topics in data from detailed in-person interviews collected for a completed population-based case-control study of HD in women that had a high response rate, histologically re-reviewed diagnoses, and nearly complete data on 312 cases and 325 random-digit dialing controls frequency-matched to cases on age and race. With logistic regression, we will compute odds ratios to estimate risk associated with: adult height; relative height at ages 8 and 12; birth weight; weight adjusted for height through adulthood; and frequency of leisure-time strenuous physical activity through adolescence and adulthood and physical activity estimated for the longest-held occupation. All analyses will be adjusted for childhood social class, comorbidities, life-time smoking, and other confounders. We will have very good statistical power to detect odds ratios >=2.0, given likely risk factor prevalences. Interactions will be addressed through stratification of analyses by age group, race, histologic type, and EBV in tumor cells, as numbers permit; interactions between variables measuring childhood exposure and body size and physical activity will be considered in regression models. Study strengths include: 1) examination of under-studied risk factors novel for women; 2) a population basis; 3) strong data quality; 4) good to excellent statistical power; 5) re-reviewed diagnoses; 6) life-time body size and physical activity data; 7) detailed data on confounders. Study weaknesses include: 1) self-reported data; 2) limitation to strenuous leisure-time physical activity; 3) poor statistical power to examine associations in some subgroups; 4) potential recall bias and modest selection bias in controls.

描述（由申请人提供）： 何杰金氏病（HD）是一种常见的癌症，其病因远未确定，很少有新的线索已被确定。零散的报告将HD风险与较高的身高，较重的体重和较少的体力活动联系起来。体型和体力活动被认为会影响免疫功能和激素调节，两者都被认为与HD病因相关，但它们对HD风险的影响很少被考虑，特别是在女性中。我们建议检查女性HD的风险与终生的身体大小和体力活动相关，以检验以下假设：1）成年身高和儿童期相对身高与HD风险增加相关。2)出生体重和整个成年期身高（体重指数）调整后的体重与HD风险相关。3)在青春期和成年期进行剧烈体力活动的频率与HD风险相关。我们将在一项已完成的基于人群的HD女性病例对照研究中收集详细的面对面访谈数据，这些数据具有高应答率，组织学重新审查诊断，以及312例病例和325例随机数字拨号控制的几乎完整的数据，这些数据与年龄和种族病例频率匹配。通过逻辑回归，我们将计算比值比来估计与以下因素相关的风险：成年身高; 8岁和12岁时的相对身高;出生体重;成年后身高调整后的体重;以及青少年和成年期的休闲时间剧烈体力活动的频率和最长职业的体力活动估计。所有分析都将根据儿童社会阶层、合并症、终生吸烟和其他混杂因素进行调整。我们将有很好的统计能力来检测比值比>=2.0，考虑到可能的风险因素患病率。如果数量允许，将通过按年龄组、种族、组织学类型和肿瘤细胞中的EBV对分析进行分层来解决相互作用;将在回归模型中考虑测量儿童期暴露与体型和体力活动的变量之间的相互作用。研究优势包括：1）检查未充分研究的女性新风险因素; 2）人群基础; 3）强大的数据质量; 4）良好至优秀的统计功效; 5）重新审查诊断; 6）终生体型和体力活动数据; 7）混杂因素的详细数据。研究弱点包括：1）自我报告的数据; 2）限制剧烈的休闲时间体力活动; 3）在某些亚组中检查关联的统计能力较差; 4）控制组中潜在的回忆偏倚和适度的选择偏倚。