AUDITORY TECTO-THALAMIC PATHWAYS--INFORMATION PROCESSING

听觉丘脑通路——信息处理

• 批准号: 3461778
• 负责人: JEFFREY JAMES WENSTRUP
• 金额: $ 11.39万
• 依托单位: NORTHEAST OHIO MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-12-01 至 1995-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3461778
• 关键词: Chiroptera; acoustic nerve; auditory cortex; auditory pathways; binaural hearing; cochlear implants; inferior colliculus; medial geniculate body; neural information processing; neurophysiology; stereotaxic techniques; thalamus

Acoustic behavior relies on information conveyed by multiple pathways projecting from the inferior colliculus to the medial geniculate body, and then to the auditory cortex. The long term goal of this research is to evaluate information processing within these auditory pathways. The proposed research will specifically examine the organization of projections from the inferior colliculus to the medial geniculate body, and the physiological properties of neurons in the medial geniculate. Special attention will be placed on connections and mechanisms involved in sound localization and in the integration of acoustic information from different frequency bands. Binaural responses and sound localization cues are organized within isofrequency representations of the mustached bat's inferior colliculus. The ascending projections of the inferior colliculus will be studied by placing deposits of anterograde tracer in regions defined physiologically by their responses to binaural input and sound frequency. Two anterograde tracers, placed in dfferent binaural subdivisions, will be used to evaluate the degree of convergent input from binaural subdivisions in the inferior colliculus. Then, physiological studies of single and multi-unit responses in the medial geniculate will evaluate the physiology and functional organization of binaural responses. These studies will establish what information regarding binaural cues is conveyed from the inferior colliculus to the medial geniculate body, and how this information is processed by neurons within the medial geniculate. It will furthermore provide the basis for a deeper understanding of how the auditory cortex processes and represents binaural cues related to sound localization, and thus underlies this important acoustic behavior. Neuml mechanisms analyzing sound location and other acoustic features may depend upon the integration of information across different isofrequency representations. The convergence of frequency-specific input from the inferior colliculus onto subdivisions of the medial geniculate will be studied by placing deposits of two anterograde tracers in different frequency represenations of the inferior colliculus. Physiological studies of single units in the medial geniculate will then confirm the organization of convergent input, and identify the physiological responses of such neurons. These studies will provide information regarding integrative mechanisms by which sound location and other acoustic features are analyzed within the auditory system.

声学行为依赖于多种途径传递的信息 从下丘向内侧膝状体突出， 然后到达听觉皮层这项研究的长期目标是 评估这些听觉通路中的信息处理。的 拟议的研究将专门审查预测的组织 从下丘到内侧膝状体， 内侧膝状体神经元的生理特性。特别 注意力将放在声音的连接和机制上。 定位和整合来自不同地区的声学信息 频段。 双耳响应和声音定位线索被组织在 这是胡子蝙蝠下丘的等距图示。 下丘的上行投射将通过 将顺行示踪剂的沉积物放置在生理上限定的区域中 通过他们对双耳输入和声音频率的反应。两个顺行 示踪剂，放置在不同的双耳分区，将用于评估 来自下丘脑中双耳细分的会聚输入的程度 丘然后，单单位和多单位反应的生理学研究 在内侧膝状体将评估生理和功能 双耳响应的组织。这些研究将确定 关于双耳提示的信息从下声道 丘的内侧膝状体，以及这些信息是如何 由内侧膝状体内的神经元处理。它还将 为更深入地了解听觉皮层 处理并表示与声音定位相关的双耳线索，以及 从而成为这种重要声学行为的基础。 分析声音位置和其他声学特征的Neuml机制可以 依赖于跨不同信息系统的信息集成 表示。频率特定输入的收敛性 下丘到内侧膝状体的细分将是 通过将两种顺行示踪剂沉积在不同的 下丘的频率表示。生理学研究 内侧膝状体中的单个单位将确认组织 的收敛输入，并确定这种生理反应， 神经元这些研究将提供有关综合信息 分析声音位置和其他声学特征的机制 在听觉系统中。