PEPTIDE MODULATION OF MESOLIMBIC DOPAMINE: BEHAVIORAL A
PEPTIDE MODULATION OF MESOLIMBIC DOPAMINE: BEHAVIORAL A
批准号:
3461087
负责人:
Ann E. Kelley
金额:
$6.84万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1990
资助国家:
美国
项目状态:
已结题
起止时间:
1990-08-01 至 1993-05-01
关键词:
auditory discrimination behavior brain mapping chemical stimulation computer data analysis dopamine dopamine receptor drug interactions dynorphins endogenous opioid enkephalins laboratory rat limbic system microinjections neuroanatomy neuropharmacology neurotensin peptide analog perception prosencephalon psychological reinforcement psychomotor function reinforcer sensory discrimination stereotaxic techniques substance P tegmentum
中文摘要
中脑边缘多巴胺(DA)系统,起源于
英文摘要
The mesolimbic dopamine (DA) system, which originates in the
ventral tegmental area (VTA) and projects to limbic forebrain
regions, plays a crucial role in mediating several important
aspects of behavior. Mesolimbic DA neurons have been shown to
be involved in such diverse functions as facilitation of motor
output, reinforcement (including mediation of the rewarding
properties of drugs of abuse), sensory and attentional processes.
Surrounding these DA neurons are multiple networks of
neuropeptide-containing nerve fibers, such as those containing
opioid peptides, tachykinins, and neurotensin. Biochemical and
behavioral experiments have suggested that these peptides have
an important modulatory influence on the activity of mesolimbic
DA neurons. Given the multiplicity of functions ascribed to the
DA neurons and the striking diversity of peptidergic innervation
associated with them, it would seem likely that their differential
peptidergic modulation may constitute the substrate of different
behavioral processes. The major objective of this project is to
determine what specific behavioral processes these peptide-DA
interactions are mediating. To accomplish this goal, paradigms
which are able to distinguish drug effects on reinforcement,
motor and sensory processes will be integrated with central
microinfusion of putative peptide neurotransmitters. This will
enable anatomically and chemically specific manipulations of VTA
neuronal subpopulations, and evaluation of the behavioral state
induced by the peptides. This investigation has direct relevance
to the problem of drug abuse, which is a major medical and social
problem. Of particular concern at the present moment are
stimulant drugs such as cocaine and amphetamine, as well as
opiate substances. There is convincing evidence that these two
classes of drugs act on the mesolimbic dopamine system to
produce a highly reinforcing behavioral state. Thus further study
of the basic mechanisms of endogenous peptides which modulate
this system may contribute to our understanding of how
psychostimulant and opiate drugs produce their psychological
effects, and may also help the development of new therapeutic
treatment of drug addiction. Moreover, the proposed experiments
specifically examine how peptide-dopamine interactions
contribute to brain mechanisms of reward and motivation, which
may further increase our knowledge of the reinforcing properties
of self-administered drugs.
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会议论文
Shortened sleep and food motivation: hypothalamic and striatal substrates
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批准号:7173944
-
项目类别:
-
资助金额:$36.75万
-
财政年份:2006
-
负责人:Ann E. Kelley
-
依托单位:
OPIOID SYSTEMS IN VENTRAL STRIATUM AND FOOD REWARD
-
批准号:2122459
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项目类别:
-
资助金额:$11.93万
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财政年份:1995
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负责人:Ann E. Kelley
-
依托单位:
OPIOID SYSTEMS IN VENTRAL STRIATUM AND FOOD REWARD
-
批准号:2122458
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项目类别:
-
资助金额:$11.63万
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财政年份:1995
-
负责人:Ann E. Kelley
-
依托单位:
OPIOID SYSTEMS IN VENTRAL STRIATUM AND FOOD REWARD
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批准号:2377407
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项目类别:
-
资助金额:$12.34万
-
财政年份:1995
-
负责人:Ann E. Kelley
-
依托单位:
NEURAL MECHANISMS IN THE NUCLEUS ACCUMBENS AND BEHAVIOR
-
批准号:6664856
-
项目类别:
-
资助金额:$4.81万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
NEURAL MECHANISMS IN THE NUCLEUS ACCUMENS AND BEHAVIOR
-
批准号:2117307
-
项目类别:
-
资助金额:$15.75万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
Plasticity and learning in a corticostriatal network
-
批准号:7281064
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项目类别:
-
资助金额:$4.1万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
NEURAL MECHANISMS IN THE NUCLEUS ACCUMENS AND BEHAVIOR
-
批准号:3210509
-
项目类别:
-
资助金额:$7.68万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
OPIOID SYSTEMS IN VENTRAL STRIATUM AND FOOD REWARD
-
批准号:6125018
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项目类别:
-
资助金额:$15.63万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
NEURAL MECHANISMS IN THE NUCLEUS ACCUMBENS AND BEHAVIOR
-
批准号:2882569
-
项目类别:
-
资助金额:$18.69万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
Plasticity and learning in a corticostriatal network
-
批准号:7033902
-
项目类别:
-
资助金额:$31.97万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
NEURAL MECHANISMS IN THE NUCLEUS ACCUMBENS AND BEHAVIOR
-
批准号:6362796
-
项目类别:
-
资助金额:$21.14万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
Plasticity and learning in a corticostriatal network
-
批准号:6872626
-
项目类别:
-
资助金额:$5.1万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
Plasticity and learning in a corticostriatal network
-
批准号:6878943
-
项目类别:
-
资助金额:$38.0万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
NEURAL MECHANISMS IN THE NUCLEUS ACCUMENS AND BEHAVIOR
-
批准号:2117306
-
项目类别:
-
资助金额:$15.84万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
NEURAL MECHANISMS IN THE NUCLEUS ACCUMENS AND BEHAVIOR
-
批准号:2117308
-
项目类别:
-
资助金额:$16.36万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
Corticostriatal-hypothalamic circuitry and food reward
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批准号:6876471
-
项目类别:
-
资助金额:$25.46万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
Corticostriatal-hypothalamic circuitry and food reward
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批准号:7027084
-
项目类别:
-
资助金额:$24.86万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
OPIOID SYSTEMS IN VENTRAL STRIATUM AND FOOD REWARD
-
批准号:6329142
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项目类别:
-
资助金额:$15.74万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
NEURAL MECHANISMS IN THE NUCLEUS ACCUMBENS AND BEHAVIOR
-
批准号:2619777
-
项目类别:
-
资助金额:$18.76万
-
财政年份:1990
-
负责人:Ann E. Kelley
-
依托单位:
国内基金
海外基金
greenwashing behavior in China:Basedon an integrated view of reconfiguration of environmental authority and decoupling logic
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批准号:--
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项目类别:外国学者研究基金项目
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资助金额:--
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批准年份:2024
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负责人:YU BYUNGJUN
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依托单位:
Incentive and governance schenism study of corporate green washing behavior in China: Based on an integiated view of econfiguration of environmental authority and decoupling logic
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批准号:--
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项目类别:外国学者研究基金项目
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资助金额:--
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批准年份:2024
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负责人:YU BYUNGJUN
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依托单位: