PHYSIOLOGY-ADRENERGIC INFLUENCE ON RENAL FLUID TRANSFER

尽管肾上腺素能神经具有重要的调节作用 肾功能系统多年来一直被怀疑，它是 只是在过去几年里，它的功能意义 该系统已经在实验中得到了充分的验证 肾小球和肾小管盐分和液体转运的调节 级别。在这项为期5年的研究项目提案中，国际和平研究所将 重点阐明其背后的生理机制 关于溶质和流态的一些令人费解的现象 在急性ECF容量耗竭动物模型上观察 充血性心力衰竭鉴于这两个条件是 以看似相似的系统环境为特征， 尤其是肾上腺素能神经活动增强，近端盐分 而水的重吸收似乎只在动物身上增强。 充血性心力衰竭。在建议的项目中，PI 目的描述近端小管运输的细节。 系统在这两种情况下的作用，并试图确定 这个运输系统中的肾上腺素能神经。此外， 将尝试测试假设的可能性，即 肾上腺素能系统的慢性激活解释了 通过影响潜在的输运模式观察到的 机械装置。由于近端小管对盐和水的重吸收 涉及跨上皮和跨毛细血管的转移 物质，实验方法包括对两者的研究 这些过程。

Although an important regulatory role of the adrenergic nervous system in renal function has been suspected for many years, it is only in the past several years that the functional significance of this system has been fully demonstrated experimentally in the regulation of salt and fluid transfer at the glomerular and tubular levels. In this proposal of 5-year research projects, the PI will focus on elucidating the physiological mechanisms which underlie the somewhat puzzling phenomena for solute and fluid patterns observed in animal models of acute ECF volume depletion and congestive heart failure. Whereas these two conditions are characterized by a seemingly similar systemic milieu, particularly, enhanced adrenergic nerve activity, proximal salt and water reabsorption appear to be enhanced only in animals with congestive heart failure. In the proposed projects, the PI intends to characterize the details of proximal tubule transport system in these two cnditions and seek to ascertain the role of the adrenergic nerves in this transport system. Furthermore, attempts will be made to test the hypothetical possibility that the chronicity of activation of the adrenergic system accounts for the observed transport patterns by affecting the underlying mechanisms. Since proximal tubule reabsorption of salt and water involves both transepithelial and transcapillary transfer of substances, the experimental approach includes studies of both of these processes.