乳腺癌获得性治疗耐药的循环肿瘤 DNA 分析-猫眼课题宝

乳腺癌获得性治疗耐药的循环肿瘤 DNA 分析

批准号：

nhmrc : 1085014

负责人：

A/Pr Sarah-Jane Dawson

金额：

$34.13万

依托单位：

The University of Melbourne

依托单位国家：

澳大利亚

项目类别：

Project Grants

财政年份：

2015

资助国家：

澳大利亚

项目状态：

已结题

起止时间：

2015-01-01 至 2017-12-31

来源：

https://researchdata.edu.au/circulating-tumour-dna-breast-cancer/519052

关键词：

Circulating tumour DNA analysis acquired

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英文摘要

Taxanes are commonly used chemotherapeutic agents in breast cancer, yet treatment resistance remains a significant clinical problem for which new approaches are needed. Many cancers shed small amounts of DNA (circulating tumor DNA (ctDNA)) into the bloodstream, and analysis of ctDNA can allow assessment of tumour specific genomic changes occurring during treatment. This project aims to utilise ctDNA to study acquired treatment resistance to taxane-based chemotherapy in metastatic breast cancer.

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