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GROWTH-INHIBITORY FACTOR ACTION ON GH4 PITUITARY CELLS

GROWTH-INHIBITORY FACTOR ACTION ON GH4 PITUITARY CELLS
生长抑制因子对 GH4 垂体细胞的作用
批准号：
3464289
负责人：
John S Ramsdell
金额：
$9.78万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
项目状态：
已结题
起止时间：
1990-07-06 至 1995-06-30
来源：
https://reporter.nih.gov/project-details/3464289
关键词：
calcium channel calcium flux cell adhesion cell cycle cell growth regulation epidermal growth factor growth factor receptors growth inhibitors pituitary gland tissue /cell culture transforming growth factors

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英文摘要
DESCRIPTION (adapted from applicant's abstract): The goal of this application is to utilize the GH4 cell line to elucidate the cellular processes by which growth factors inhibit pituitary cell proliferation. It is proposed to investigate several aspects of TGF-alpha and TGF-beta growth-inhibitory mechanisms. First, it will be examined whether TGF-alpha or TGF-beta blocks specific states of the cell cycle. Then it will be examined whether TGF-alpha or TGF-beta inhibits cell proliferation by preventing the actions of defined growth-stimulatory factors, elevating free cytosolic calcium, or enhancing cell-substratum adhesion.
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GROWTH-INHIBITORY FACTOR ACTION ON GH4 PITUITARY CELLS
GROWTH INHIBITORY FACTOR ACTION ON GH4 PITUITARY CELLS
GROWTH-INHIBITORY FACTOR ACTION ON GH4 PITUITARY CELLS
GROWTH-INHIBITORY FACTOR ACTION ON GH4 PITUITARY CELLS
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