GROWTH-INHIBITORY FACTOR ACTION ON GH4 PITUITARY CELLS

生长抑制因子对 GH4 垂体细胞的作用

• 批准号: 3464289
• 负责人: John S Ramsdell
• 金额: $ 9.78万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-06 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3464289
• 关键词: calcium channel; calcium flux; cell adhesion; cell cycle; cell growth regulation; epidermal growth factor; growth factor receptors; growth inhibitors; pituitary gland; tissue /cell culture; transforming growth factors

DESCRIPTION (adapted from applicant's abstract): The goal of this application is to utilize the GH4 cell line to elucidate the cellular processes by which growth factors inhibit pituitary cell proliferation. It is proposed to investigate several aspects of TGF-alpha and TGF-beta growth-inhibitory mechanisms. First, it will be examined whether TGF-alpha or TGF-beta blocks specific states of the cell cycle. Then it will be examined whether TGF-alpha or TGF-beta inhibits cell proliferation by preventing the actions of defined growth-stimulatory factors, elevating free cytosolic calcium, or enhancing cell-substratum adhesion.

描述（改编自申请人的摘要）：本研究的目标 应用是利用GH4细胞系来阐明细胞的 生长因子抑制垂体细胞增殖的过程。 它 提出了研究TGF-α和TGF-β的几个方面， 生长抑制机制。 首先，将检查TGF-α是否 或TGF-β阻断细胞周期的特定状态。 就会去 研究了TGF-α或TGF-β是否抑制细胞增殖， 阻止确定的生长刺激因子的作用， 游离胞浆钙或增强细胞-基质粘附。