BINOCULAR INTERACTION IN HUMAN VISUAL CORTEX

双眼视力障碍的早期发现和矫正至关重要 年轻的视觉系统在敏感期的适当成熟 发展时期。一种评估双眼相互作用的技术 在人类的视皮层中，双目搏动技术(BBT)具有 显示出作为皮质双目整合的标志物的巨大前景。 这涉及到均匀场的二分辨表示，该场是 以不同时间频率对亮度进行正弦调制 两眼之间。它会引起一种独特的反应，称为“双眼节拍”。 它是反映非线性的视觉诱发电位(VEP)分量 神经行为，只有一体化的双目才能产生 单位。在正常成年人身上也可以观察到这种心跳。 有斜视或弱视的人，伴随着眼球受阻 视觉皮质中的双眼功能在这方面表现出严重的减退 非线性，提示双眼皮质突起异常 因为这种均匀磁场刺激不会流鼻涕 需要准确的调节、固定、收敛或高度空间 分辨率，这项技术作为一种工具具有巨大的潜力 婴儿双眼能力的评估。在这项提案中，以下内容 将解决神经生理和临床感兴趣的问题：1) 心跳作为双眼功能指标的临床应用， 2)婴儿双眼节拍的发育过程；3) 受试者内诱发的VEP搏动反应与VEP的比较 随机点立体图作为大脑皮层双目的指示物，4) 睡眠/清醒状态对VEP搏动反应的不同影响，5) 双眼搏动的时空方面，6)大脑皮质的拓扑结构 拍频非线性产生的机理及其他 非线性系统分析方法(包括白噪声激励) 为了探索非线性机制的本质(S)产生了 双目跳动。

Early detection and correction of binocular visual disorders are crucial for the proper maturation of the young visual system during the sensitive period of development. A technique for assessment of binocular interaction in the human visual cortex known as the Binocular Beat Technique (BBT) has shown great promise for use as a marker for cortical binocular integration. This involves the dichoptic presentation of uniform fields which are sinusoidally modulated in luminance with differing temporal frequencies between the eyes. It evokes a unique response termed the "binocular beat" which is a visual evoked potential (VEP) component reflecting nonlinear neural behavior and which could only arise from integrative binocular units. This beat can also be observed perceptually in normal adults. Individuals with strabismus or amblyopia, which accompany disrupted binocular function in the visual cortex manifest severe reductions in this nonlinearity, suggesting an abnormality in the binocular cortical processes underlying this response Because this uniform-field stimulus doe snot require accurate accommodation, fixation, vergence or high spatial resolution, this technique has significant potential as a tool for assessment of infant binocularity. In this proposal, the following problems of neurophysiological and clinical interest will be addressed: 1) the clinical usefulness of the beat as an indicant of binocular function, 2) the developmental course of the binocular beat in infants, 3) intrasubject comparison between the VEP beat response and VEP elicited by random-dot stereograms as an indicant of cortical binocularity, 4) the differential effects of sleep/awake states on the VEP beat responses, 5) spatiotemporal aspects of the binocular beat, 6) cortical topology of the mechanisms generating the beat nonlinearity and 7) application of other nonlinear systems analysis approaches (including white-noise stimulation) for exploring the nature of the nonlinear mechanism(s) producing the binocular beat.