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Binocular vision after long-term adaptation to ocular optics

长期适应眼光学后的双眼视觉

基本信息

批准号：
10540870
负责人：
GEUNYOUNG YOON
金额：
$ 44.15万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-15 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10540870
关键词：
Adult Affect Appearance Binocular Vision Bypass Characteristics Chronic Contrast Sensitivity Corneal Diseases Custom Data Defect Depth Perception Exposure to Eye Eye Movements Frequencies Goals Hour Human Image Impairment Keratoconus Left Monocular Vision Neuronal Plasticity Neurophysiology - biologic function Ocular Dominance Optics Patients Perception Perceptual learning Performance Phase Play Process Property Psychophysics Refractive Errors Resolution Role Sensory Stimulus System Testing Thinking Training Variant Vision Visual Visual Acuity Visual Fields Visual system structure Work adaptive optics base design experience improved innovation insight lens monocular neuroadaptation neuromechanism neurotransmission novel relating to nervous system response retinal imaging sample fixation tool visual deprivation visual performance visual processing

项目摘要

It is well known that the optics of the human eye limit many aspects of visual function including visual acuity and contrast sensitivity. Less is known about how the eyes’ optics affect binocular vision. There is clear evidence that optics affect both stereopsis and binocular summation. Interestingly, inter-ocular differences in optics impede some aspects of binocular function while facilitating others. Moreover, our previous studies found that in eyes with prolonged visual deprivation induced by the abnormally large optical defects such as aberrations, neural processing of both contrast and phase of retinal images are altered. Our preliminary studies have also shown that binocular visual functions e.g. binocular summation, subjective image quality and stereo-resolution are determined by strong binocular neural interaction with the optical profiles of the two eyes. We are now ready to distinguish contributions of optical and neural factors to binocular vision, including in patients with the corneal disease called keratoconus (KC). With this unique condition, a normally developed visual system suffers optical degradation in adulthood, thus providing opportunity to study adaptation to induced optical aberrations on binocular visual function. We will utilize innovative advanced correction tools, a binocular adaptive optics vision simulator and a customized scleral lens for short-term and long-term precise aberration correction/manipulation to study (1) the effects of optics on binocular combination of dissimilar monocular images, (2) contributions of binocular optics to human stereopsis and (3) binocular neural plasticity stimulated by improved optics and binocular perceptual learning. Aim 1 is designed to investigate the mechanisms that underlie binocular combination of dissimilar retinal images induced by inter-ocular differences in the eye’s optics. This is achieved by testing the hypothesis that the human visual system can achieve binocular combination of neural signals arising from left- and right-eye images in a manner that enhances the global binocular image quality via interocular processes operating over local regions of visual space in an eye-selective manner (1.1), by characterizing changes in sensory dominance induced by long- term adaptation to eye’s optics (1.2) and by testing the hypothesis that dissimilar monocular aberrations alter phase perception of a broadband stimulus differently in the two eyes, resulting in reduced binocular advantages and inter- ocular inhibition in some severe cases. Aim 2 is to investigate both optical and neural factors including aberrations, fixational eye movements and long-term neural adaptation in human stereopsis. Aim 3 will assess the extent to which binocular plasticity that occurs during long-term adaptation is reversible and what mechanistic changes underlie this reversal once aberration-free image quality in the two eyes is achieved in KC eyes. Successful completion of these specific aims will produce fundamental insights into human binocular vision, specifically the relationship between ocular optics and the binocular neural adaptive process.

众所周知，人眼的光学结构限制了视觉功能的许多方面，包括视敏度和视力

项目成果

期刊论文数量（33）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（1）

Wavefront-guided scleral lens prosthetic device for keratoconus.

DOI：
10.1097/opx.0b013e318288d19c
发表时间：
2013-04
期刊：
Optometry and vision science : official publication of the American Academy of Optometry
影响因子：
0
作者：
Sabesan R;Johns L;Tomashevskaya O;Jacobs DS;Rosenthal P;Yoon G
通讯作者：
Yoon G

Scanning system design for large scan depth anterior segment optical coherence tomography.

DOI：
10.1364/ol.35.001774
发表时间：
2010-06
期刊：
Optics letters
影响因子：
3.6
作者：
R. Yadav;Kamran Ahmad;G. Yoon
通讯作者：
R. Yadav;Kamran Ahmad;G. Yoon

Vision improvement by correcting higher-order aberrations with customized soft contact lenses in keratoconic eyes.

通过使用定制的软性隐形眼镜矫正圆锥角膜眼睛的高阶像差来改善视力。

DOI：
10.1364/ol.32.001000
发表时间：
2007
期刊：
Optics letters
影响因子：
3.6
作者：
Sabesan,Ramkumar;Jeong,TaeMoon;Carvalho,Luis;Cox,IanG;Williams,DavidR;Yoon,Geunyoung
通讯作者：
Yoon,Geunyoung

Binocular accommodative response with extended depth of focus under controlled convergences.