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Binocular vision after long-term adaptation to ocular optics

长期适应眼光学后的双眼视觉

基本信息

批准号：
10540870
负责人：
GEUNYOUNG YOON
金额：
$ 44.15万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-15 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10540870
关键词：
Adult Affect Appearance Binocular Vision Bypass Characteristics Chronic Contrast Sensitivity Corneal Diseases Custom Data Defect Depth Perception Exposure to Eye Eye Movements Frequencies Goals Hour Human Image Impairment Keratoconus Left Monocular Vision Neuronal Plasticity Neurophysiology - biologic function Ocular Dominance Optics Patients Perception Perceptual learning Performance Phase Play Process Property Psychophysics Refractive Errors Resolution Role Sensory Stimulus System Testing Thinking Training Variant Vision Visual Visual Acuity Visual Fields Visual system structure Work adaptive optics base design experience improved innovation insight lens monocular neuroadaptation neuromechanism neurotransmission novel relating to nervous system response retinal imaging sample fixation tool visual deprivation visual performance visual processing

项目摘要

It is well known that the optics of the human eye limit many aspects of visual function including visual acuity and contrast sensitivity. Less is known about how the eyes’ optics affect binocular vision. There is clear evidence that optics affect both stereopsis and binocular summation. Interestingly, inter-ocular differences in optics impede some aspects of binocular function while facilitating others. Moreover, our previous studies found that in eyes with prolonged visual deprivation induced by the abnormally large optical defects such as aberrations, neural processing of both contrast and phase of retinal images are altered. Our preliminary studies have also shown that binocular visual functions e.g. binocular summation, subjective image quality and stereo-resolution are determined by strong binocular neural interaction with the optical profiles of the two eyes. We are now ready to distinguish contributions of optical and neural factors to binocular vision, including in patients with the corneal disease called keratoconus (KC). With this unique condition, a normally developed visual system suffers optical degradation in adulthood, thus providing opportunity to study adaptation to induced optical aberrations on binocular visual function. We will utilize innovative advanced correction tools, a binocular adaptive optics vision simulator and a customized scleral lens for short-term and long-term precise aberration correction/manipulation to study (1) the effects of optics on binocular combination of dissimilar monocular images, (2) contributions of binocular optics to human stereopsis and (3) binocular neural plasticity stimulated by improved optics and binocular perceptual learning. Aim 1 is designed to investigate the mechanisms that underlie binocular combination of dissimilar retinal images induced by inter-ocular differences in the eye’s optics. This is achieved by testing the hypothesis that the human visual system can achieve binocular combination of neural signals arising from left- and right-eye images in a manner that enhances the global binocular image quality via interocular processes operating over local regions of visual space in an eye-selective manner (1.1), by characterizing changes in sensory dominance induced by long- term adaptation to eye’s optics (1.2) and by testing the hypothesis that dissimilar monocular aberrations alter phase perception of a broadband stimulus differently in the two eyes, resulting in reduced binocular advantages and inter- ocular inhibition in some severe cases. Aim 2 is to investigate both optical and neural factors including aberrations, fixational eye movements and long-term neural adaptation in human stereopsis. Aim 3 will assess the extent to which binocular plasticity that occurs during long-term adaptation is reversible and what mechanistic changes underlie this reversal once aberration-free image quality in the two eyes is achieved in KC eyes. Successful completion of these specific aims will produce fundamental insights into human binocular vision, specifically the relationship between ocular optics and the binocular neural adaptive process.

众所周知，人眼的光学系统限制了视觉功能的许多方面，包括视敏度和对比敏感度。人们对眼睛的光学系统如何影响双眼视觉知之甚少。有明确证据表明光学影响立体视觉和双眼求和。有趣的是，眼间光学差异阻碍了一些双眼功能的各个方面，同时促进其他方面。此外，我们之前的研究发现，在眼睛中由异常大的光学缺陷（例如像差、神经处理）引起的长期视觉剥夺视网膜图像的对比度和相位都发生改变。我们的初步研究还表明，双眼视觉功能，例如双目求和，主观图像质量和立体分辨率由强双眼神经与两只眼睛的光学轮廓的相互作用。我们现在准备区分贡献光学和神经因素对双眼视觉的影响，包括患有圆锥角膜的角膜疾病的患者（KC）。由于这种独特的条件，正常发育的视觉系统在成年后会遭受光学退化，因此提供了研究双眼视觉功能诱发光学像差的适应的机会。我们将利用创新的先进矫正工具、双目自适应光学视觉模拟器和定制巩膜镜短期和长期精确像差校正/操纵，以研究（1）光学对双目的影响不同单目图像的组合，(2) 双目光学对人类立体视觉的贡献，以及 (3) 通过改进的光学和双眼感知学习刺激双眼神经可塑性。目标 1 旨在研究不同视网膜图像的双眼组合背后的机制由眼睛光学系统的眼间差异引起。这是通过检验人类的假设来实现的视觉系统可以实现左眼和右眼图像产生的神经信号的双目组合通过在局部区域上操作的眼间过程来增强全局双目图像质量的方式通过表征长期观察引起的感觉优势的变化，以眼睛选择性的方式（1.1）观察视觉空间术语适应眼睛的光学（1.2）并通过测试不同的单眼像差改变相位的假设两只眼睛对宽带刺激的感知不同，导致双眼优势和间视效应降低。某些严重病例会出现眼部抑制。目标 2 是研究光学和神经因素，包括像差、人类立体视觉中的注视眼球运动和长期神经适应。目标 3 将评估以下程度：长期适应过程中发生的哪些双眼可塑性是可逆的以及机制发生了什么变化一旦 KC 眼实现两只眼睛的无像差图像质量，就会出现这种逆转。成功完成这些具体目标将对人类双眼视觉产生基本的见解，特别是眼光学和双眼神经适应过程之间的关系。

项目成果

期刊论文数量（33）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（1）

Wavefront-guided scleral lens prosthetic device for keratoconus.

DOI：
10.1097/opx.0b013e318288d19c
发表时间：
2013-04
期刊：
Optometry and vision science : official publication of the American Academy of Optometry
影响因子：
0
作者：
Sabesan R;Johns L;Tomashevskaya O;Jacobs DS;Rosenthal P;Yoon G
通讯作者：
Yoon G

Scanning system design for large scan depth anterior segment optical coherence tomography.

DOI：
10.1364/ol.35.001774
发表时间：
2010-06
期刊：
Optics letters
影响因子：
3.6
作者：
R. Yadav;Kamran Ahmad;G. Yoon
通讯作者：
R. Yadav;Kamran Ahmad;G. Yoon

Vision improvement by correcting higher-order aberrations with customized soft contact lenses in keratoconic eyes.

通过使用定制的软性隐形眼镜矫正圆锥角膜眼睛的高阶像差来改善视力。

DOI：
10.1364/ol.32.001000
发表时间：
2007
期刊：
Optics letters
影响因子：
3.6
作者：
Sabesan,Ramkumar;Jeong,TaeMoon;Carvalho,Luis;Cox,IanG;Williams,DavidR;Yoon,Geunyoung
通讯作者：
Yoon,Geunyoung

Binocular accommodative response with extended depth of focus under controlled convergences.