Clamp stabilized vaccines to provide broad spectrum protection against influenza

钳位稳定疫苗可提供广谱流感保护

• 批准号: nhmrc : GNT1156063
• 负责人: Dr Daniel Watterson
• 金额: $ 94.95万
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/clamp-stabilized-vaccines-protection-influenza/1349201
• 关键词: Clamp; stabilized; vaccines; provide; broad

Protection against disease provided by current influenza vaccines is limited by narrow virus strain specificity. We developed a novel ‘molecular clamp’ technology that constrains the major viral immune target into its native structure. Immunization results in immune responses with increased virus killing and improvements in cross-reactivity and protection against divergent viruses. Our approach will be further developed and compared to current commercial vaccines.

目前的流感疫苗提供的针对疾病的保护受到狭窄的病毒株特异性的限制。我们开发了一种新的“分子钳”技术，将主要的病毒免疫靶标限制在其天然结构中。免疫接种导致免疫应答，增加了病毒杀伤，改善了交叉反应性和对不同病毒的保护。我们的方法将进一步发展，并与目前的商业疫苗进行比较。