MATERNAL WEIGHT GAIN AND FETAL OUTCOME

产妇分娩时的总体重增加一直与 出生体重和围产儿死亡率，因此目前的指南 对于产前护理，强调足够的产妇体重的重要性 怀孕期间的收益。然而，因为总的体重增加并不是 在分娩前提供，临床医生转而依赖于 母体体重增加可以在怀孕期间测量 怀孕了。尽管这种方法是实用的，并且被推定为 在预测不良妊娠结局方面很有用，但已经很少了 孕期体重比体重增加规律的研究 在交付时获得收益。 我们计划研究自1980年以来分娩的16,000多名孕妇 通过一系列总结，找出母亲体重增加的模式 在参数模型中，预测妊娠结局。多变量模型 将被用来探索母亲体重模式的影响 胎儿出生体重、早产和其他结局的增加， 将特别关注以下孕妇亚群： 胎儿结局不良的风险特别高。最后，我们将定义 并测试怀孕期间体重增加的最佳模式 在临床环境中用于识别符合以下条件的个别妊娠 更有可能进展正常，而不是那些有可能进展的 开发问题。预计这项研究将有助于 女性在怀孕期间体重增加的建议，给 监测产前体重增加的有效性，并最终达到 改善新生儿及其母亲的健康。

Total maternal weight gain at delivery has been consistently associated with both birth weight and perinatal mortality, thus current guidelines for prenatal care emphasize the importance of an adequate maternal weight gain during pregnancy. However, because total weight gain is not available prior to delivery, clinicians depend instead on the pattern of maternal weight gain that can be measured during the course of a pregnancy. Although this approach is practical, and is presumed to be useful in predicting poor pregnancy outcomes, there has been much less investigation of pattern of weight gain during pregnancy than the weight gain at delivery. We propose to study more than 16,000 pregnancies delivered since 1980 to identify how the pattern of maternal weight gain, summarized by a series of parametric models, predicts pregnancy outcome. Multivariate models will be used to explore the influence of the pattern of maternal weight gain on fetal birth weight, preterm delivery, and other outcomes, with special attention will be focused on subgroups of pregnant women who are at particularly high risk for poor fetal outcome. Finally, we will define and test an optimal pattern of weight gain during pregnancy that can be used in the clinical setting to identify individual pregnancies that are more likely to progress normally, as opposed to those which are likely to develop problems. It is expected that this study will contribute to the advice women are given about weight gain during pregnancy, to the effectiveness of monitoring prenatal weight gain and ultimately to improvement of health of newborn infants and their mothers.