MATERNAL WEIGHT GAIN AND FETAL OUTCOME

分娩时母体总体重增加一直与 与出生体重和围产期死亡率有关，因此目前的指南 产前护理强调孕妇体重的重要性 怀孕期间获得。 然而，由于总体重增加不是 在分娩前可用，临床医生反而依赖于 母亲的体重增加，可以在一个过程中测量 怀孕 尽管这种方法是实用的，并且被认为是 在预测不良妊娠结局方面， 妊娠期体重增加模式的研究 交货时的收益。 我们建议研究1980年以来分娩的16,000多名孕妇， 确定母亲体重增加的模式，总结了一系列 参数模型，预测妊娠结局。 多变量模型 将被用来探讨母亲体重模式的影响， 胎儿出生体重增加、早产和其他结局， 将特别关注以下孕妇群体： 胎儿预后不良的风险特别高。 最后，我们将定义 并测试怀孕期间体重增加的最佳模式， 在临床环境中用于识别个体妊娠， 更有可能正常进展，而不是那些可能 发展问题。 预计这项研究将有助于 建议妇女在怀孕期间体重增加， 监测产前体重增加的有效性， 改善新生儿及其母亲的健康。

Total maternal weight gain at delivery has been consistently associated with both birth weight and perinatal mortality, thus current guidelines for prenatal care emphasize the importance of an adequate maternal weight gain during pregnancy. However, because total weight gain is not available prior to delivery, clinicians depend instead on the pattern of maternal weight gain that can be measured during the course of a pregnancy. Although this approach is practical, and is presumed to be useful in predicting poor pregnancy outcomes, there has been much less investigation of pattern of weight gain during pregnancy than the weight gain at delivery. We propose to study more than 16,000 pregnancies delivered since 1980 to identify how the pattern of maternal weight gain, summarized by a series of parametric models, predicts pregnancy outcome. Multivariate models will be used to explore the influence of the pattern of maternal weight gain on fetal birth weight, preterm delivery, and other outcomes, with special attention will be focused on subgroups of pregnant women who are at particularly high risk for poor fetal outcome. Finally, we will define and test an optimal pattern of weight gain during pregnancy that can be used in the clinical setting to identify individual pregnancies that are more likely to progress normally, as opposed to those which are likely to develop problems. It is expected that this study will contribute to the advice women are given about weight gain during pregnancy, to the effectiveness of monitoring prenatal weight gain and ultimately to improvement of health of newborn infants and their mothers.