Clarifying Shared and Unique Neurocognitive Processes across Depression and Dementia

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Depressive features in late-life frequently co-occur with cognitive decline, but are often treated by clinicians as distinct. Despite this, depressive symptoms increase the risk of dementia, suggesting a degree of overlap in illness trajectories. This project will apply novel analytic methods to clarify neurobiological predictors of cognitive decline in those with depression, and quantify common and unique brain-based biomarkers across those with established depression and dementia.