Unique and shared functions of KAT6A and KAT6B

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The way in which the genetic material and associated proteins, termed chromatin, are packaged in the nucleus regulates gene activity. In cancer cells, the chromatin structure is highly abnormal. We propose to investigate the combined function of two proteins, which regulate chromatin structure and cause leukaemia when abnormally active. We are developing new drugs targeting these proteins. This project will inform how best to use these drugs in designing new therapies for cancer.