PLASMA SKIMMING IN MICROVASCULAR BIFURCATIONS

微血管分叉处的血浆撇取

• 批准号: 3471088
• 负责人: RUSSELL T CARR
• 金额: $ 9.43万
• 依托单位: UNIVERSITY OF NEW HAMPSHIRE
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3471088
• 关键词: computer simulation; erythrocytes; fluorescent dye /probe; hemodynamics; mathematical model; microcirculation; model design /development

The proposed research will provide data on plasma skimming from in vitro experiments. Two geometries will be investigated, two bifurcations in series, and single bifurcations with unequal branch diameters. Measurements of red cell velocity and red cell flux in each branch will be performed using the red cell fluorescent labeling technique of Sarelius and Duling (1982). The data from this research will be helpful to in vivo microcirculationists and those researchers developing computer models to analyze hemodynamics in branching networks. In vivo microcirculationists will be better equipped to interpret their experimental results on network blood flow. The proposed experiments will provide computer modelers with data on the partition of red cells in vessel junctions. These data will fill one of the major needs to improve current models (Popel, 1980). This research is applicable to the physiological problems of blood flow regulation and oxygen delivery. It also has application to computer simulation experiments, which cannot be performed in vivo, in vascular disease research.

拟议中的研究将提供有关血浆撇除的数据， 体外实验 将研究两种几何形状， 串联分叉和不等分支单分叉 直径。 红细胞速度和红细胞流量的测定 每个分支将使用红细胞荧光 Sarelius和Duling（1982）的标记技术。 本研究的数据将有助于在体内 微循环学家和那些开发计算机 模型来分析分支网络中的血液动力学。 体内 微循环学家将更好地解释他们的 网络血流的实验结果。 拟议 实验将为计算机建模者提供有关 血管连接处红细胞的分配。 这些数据将填补一个 改进现有模型的主要需求（Popel，1980）。 这项研究适用于血液的生理问题 流量调节和氧气输送。 它也适用于 计算机模拟实验，这不能在 在血管疾病的研究中。