Putting Low Coordination into Practice by the Exploration of Metal-sigma-Interactions: Fundamentals, New Catalysts and Catalysis for New Materials

通过探索金属-西格玛相互作用将低配位付诸实践：基础知识、新催化剂和新材料催化

• 批准号: EP/M024210/2
• 负责人: Andrew Weller
• 金额: $ 64.74万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM024210%2F2
• 关键词: Putting; Low; Coordination; into; Practice

The manipulation of chemical bonds to provide materials and chemicals of intrinsic value in the most energy and resource efficient way is at the heart of Chemistry. Catalysis is a cornerstone of this endeavour, contributing directly to the chemical industry in the UK (it is estimated that ~ 75% of all chemicals require catalysts in their manufacture), a manufacturing sector that generates ~21% of UK GDP. Transition metal-based systems play a central role in catalysis, often offering mechanistically distinct routes to molecules that could not be made by other means. The molecules thus produced may be of very high value/low volume, e.g. an intermediate in sophisticated synthetic route to a pharmaceutical; or lower relative value/high volume, e.g. polyolefins from fossil-resource derived hydrocarbons. The design, construction and implementation of new catalysts that offer step-changes in chemical manufacturing capability, in concert with improving the fundamental understanding of how chemical bonds can be manipulated, is thus central to: sustainable manufacturing, energy and resource security, and healthcare. This Fellowship will allow for the study of two highly complementary strands of catalysis discovery, development and application, that capitalise on exciting emerging results from the Weller group. The scientific aim of the Fellowship is to develop, and harness in real-world applications, the fundamental and catalytic chemistry associated with the synthesis, characterisation and utilisation of metal sigma-complexes. It is both fundamental and applied in scope, broad in its vision, and will allow for the opening up of new areas in organometallic chemistry and main-group materials chemistry. Such challenging goals would have been unreasonable until very recently, but the breakthroughs in the applicant's laboratories set the scene for these significant future developments in the field. The programme will push back the limits of what can be achieved in the synthesis of reactive organometallic compounds, their use in catalysis for the manufacture of new, and exciting, types of polymeric materials and the efficient utilisation of fossil-resource derived chemical feedstocks (alkanes) and catalysts for fine chemicals synthesis (C-H activation).

对化学键以最有效的能源和资源有效方式提供内在价值的材料和化学物质的操纵是化学核心。催化是这项努力的基石，直接对英国的化学工业做出了贡献（估计约有75％的化学物质需要催化剂制造），这是一个产生英国GDP约21％的制造业。基于过渡金属的系统在催化中起着核心作用，通常为无法通过其他方式制成的分子提供机械不同的路线。因此产生的分子可能具有很高的值/低体积，例如进入药物的复杂合成途径的中间体；或较低的相对值/高体积，例如来自化石资源衍生的碳氢化合物的聚烯烃。因此，新的催化剂的设计，建设和实施提供了化学制造能力的逐步变化，同时提高了对化学键如何操纵的基本了解，因此对于：可持续的制造，能源和资源安全以及医疗保健至关重要。该奖学金将允许研究两条高度互补的催化发现，开发和应用，这些链接利用了Weller Group的令人兴奋的新兴结果。团契的科学目的是发展和利用现实世界中的应用，与金属sigma-complexes的合成，表征和利用相关的基本和催化化学。它既是基本的范围，又广泛的视野，并且可以开放有机金属化学和主群材料化学中的新领域。这种具有挑战性的目标直到最近才是不合理的，但是申请人实验室的突破为该领域的这些重大未来发展设定了现场。该程序将推迟在合成反应性有机金属化合物中可以实现的局限性，它们用于催化用于制造新的，令人兴奋的，令人兴奋的聚合物材料的类型以及有效利用化石衍生的化学化学物质原料（Alkanes）以及用于美化学物质综合的化学化学物质原料（Alkanes）和催化剂）。