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REGULATION OF CARDIAC MASS IN AORTIC REGURGITATION

主动脉瓣反流中心脏质量的调节

基本信息

批准号：
3472109
负责人：
NORMAN M MAGID
金额：
$ 11.09万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-04-01 至 1993-03-31
项目状态：
已结题

项目摘要

The objective of this proposal is to define the alterations in myocardial protein metabolism that regulate the responses to acute and chronic volume overload in an intact animal model of aortic regurgitation. The relative contributions of cardiac protein synthesis and degradation to the structural remodelling that occurs during the development of left ventricular dilatation and eccentric hypertrophy will be examined. The effects of the severity and chronicity of volume overload on synthesis and degradation rates of total cardiac protein, individual myofibrillar proteins and collagen will be investigated. The hypothesis to be tested is that specific and total cardiac protein degradation rates as well as synthesis rates are fundamentally important to the regulation of cardiac protein mass during the left ventricular dilation and eccentric hypertrophy that develop in response to chronic volume overload. Thus we will examine the biochemical mechanisms underlying the structural and functional responses to chronic aortic regurgitation. The process of testing our hypothesis can be expected to improve understanding of cardiac protein regulation in vivo. Specifically, it is hoped that these studies may allow identification of protein metabolic abnormalities that could prove useful as indices of degeneration for timing of valve replacement, or which might provide insights helpful in the design of new therapeutic approaches to retarding the effects of volume loading.

该提案的目的是定义以下方面的变更：调节反应的心肌蛋白质代谢完整动物模型中的急性和慢性容量超负荷主动脉瓣关闭不全。心脏蛋白的相对贡献合成和降解到结构重塑发生在左心室扩张的发展过程中将检查偏心肥大。的影响合成和容量超负荷的严重性和长期性总心脏蛋白、个体肌原纤维的降解率将研究蛋白质和胶原蛋白。假设为测试的是特定的和总的心脏蛋白质降解率以及合成速率对于左心室期间心脏蛋白质质量的调节因响应而发展的扩张和偏心肥大慢性容量超负荷。因此我们将检查生化结构和功能反应的潜在机制慢性主动脉瓣关闭不全。测试我们的过程假设假设有望提高对心脏的理解体内蛋白质调节。具体来说，希望这些研究可能有助于鉴定蛋白质代谢可能被证明可用作退化指标的异常了解瓣膜更换的时机，或者可能提供见解有助于设计新的延缓治疗方法体积负载的影响。