EPIDEMIOLOGY OF CARDIOVASCULAR DISEASES IN THE ELDERLY

老年人心血管疾病的流行病学

• 批准号: 3471567
• 负责人: TRUDY L BUSH
• 金额: $ 12.15万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3471567
• 关键词: cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; cardiovascular disorder prevention; case history; disabling disease; disease /disorder proneness /risk; human mortality; human old age (65+); human subject; information systems; lifestyle; questionnaires

The objective of this research is to 1) identify and 2) describe the distribution of risk factors for cardiovascular disease (CVD) in a cohort of free-living elderly persons. The identification of risk factors for CVD in older persons is important as 1) CVD is the leading cause of death and disability in elderly Americans and 2) there is evidence that CVD can be prevented or delayed in this age group. The data were collected by the Dunedin Program, a population- based geriatric health program designed to screen persons 65+ years for a wide range of medical disorders. The Dunedin Program, located in Dunedin, Florida, has been in continuous operation since July 1975. Participants are screened annually and extensive data on CVD and risk factors are gathered at each visit. Information is available from questionnaires (i.e. family history, drug use, smoking, alcohol use), physical exams (i.e. EKGs, pulse rate, blood pressure) and laboratory measures (i.e. glucose, lipids, uric acid). Currently (1986) 5,085 men and women have been screened at least once and 1,540 persons have been screened for eight years. This participation represents 14,783 person-years of observation with an average follow-up of 4.9 years. The analysis will consist of three phases. First, follow-up time for each participant will be computed, and changes in risk factor status will be analyzed. Descriptive data on the distribution of risk factors and the prevalence of CVD in the entire cohort will be presented. CVD incidence and mortality rates will be calculated. In the second phase, incidence rates of CVD will be computed by category of risk factor level at baseline. The relative risk of CVD (incidence in exposed/incidence in unexposed) will be calculated for each hypothesized risk factor. The third phase is multivariable analyses. Regression models will be used to determine independent and interactive effects of the identified risk factors on the incidence of and mortality from CVD. This study will provide information of the prevalence and risk of CVD in a large, free-living elderly population. The identification of factors which may both increase the risk of CVD in the aged, and be modifiable/treatable is of significant public health importance, as changes in these factors may lead to further reduction of events/deaths in this large and growing segment of our population.

本研究的目的是1）识别和2）描述 心血管疾病（CVD）危险因素的分布 自由生活的老年人群体。 风险识别 老年人CVD的因素很重要，因为1）CVD是 美国老年人死亡和残疾的主要原因; 2） 有证据表明，CVD可以预防或延迟， 年龄段 这些数据是由达尼丁计划收集的，该计划是一个人口- 为65岁以上的人提供筛查的老年保健方案 多年来，各种各样的医学疾病。 达尼丁 该项目位于佛罗里达的达尼丁， 自1975年7月起运营。 每年对参与者进行筛选， 在每次访问时收集关于CVD和风险因素的广泛数据。 信息可从问卷中获得（即家族史， 药物使用、吸烟、饮酒）、体格检查（即心电图、脉搏 速率，血压）和实验室测量（即葡萄糖，脂质， 尿酸）。 目前（1986年）有5 085名男女被 至少筛查一次，1 540人已接受筛查， 八年 这一参与代表了14，783人年的 平均随访4.9年。 分析将包括三个阶段。 一、随访时间 将计算每个参与者的风险系数， 将对状态进行分析。 分布的描述性数据 风险因素和整个队列中CVD的患病率将 被介绍。 CVD发病率和死亡率将 计算了 在第二阶段，CVD的发病率将通过以下方式计算： 基线时风险因素水平的类别。 CVD的相对风险 （暴露组发生率/未暴露组发生率） 每个假设的风险因素。 第三阶段是多变量分析。 回归模型将 用于确定独立的和相互作用的影响， 确定的危险因素对发病率和死亡率从 CVD。 本研究将提供以下信息： CVD在一个大的，自由生活的老年人群。 识别 可能增加老年人心血管疾病风险的因素， 并且是可改变/可治疗的， 重要性，因为这些因素的变化可能导致进一步的 减少这一庞大且不断增长的群体中的事件/死亡 我们的人口。