King's College London Experimental Equipment

伦敦国王学院实验设备

• 批准号: EP/M028054/1
• 负责人: Chris Mottershead
• 金额: $ 102.44万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM028054%2F1
• 关键词: King; College; London; Experimental; Equipment

1. 'Advanced Materials for Nanophotonics' Advanced Materials is one of the 8 Great Technologies designated by BIS and marked by EPSRC for prioritised investment. In turn, photonics and nanophotonics is one of the most penetrating technologies of the 21st century with impact in areas of information processing, solar energy harvesting, biomedical sciences, security sensing and many others. Development of new research directions and novel applications in nanophotonics requires access to appropriate nanofabrication and characterisation equipment. The facility will combine a range of state of the art instruments for fabrication of ultrasmooth and ultrathin (< 1 nm) layers and nanostructures and their characterisation with functionalities currently not available in London. The equipment requested will strengthen present research activities in plasmonic and nanophotonics while opening up new avenues of research such as electron beam-induced nanophotonics and nanoscale quantum optics. 2. 'Single-Molecule Biophysics and Photonics'Understanding the physical mechanisms governing life has been, and still is, one of the most significant scientific challenges of humanity. The molecular mechanisms by which each individual process occurs remains largely unknown, as it requires capturing the (often fast) dynamics of an individual molecule over large periods of time. Single molecule techniques have recently allowed the tracking of individual molecules, either by the use of light (eg. fluorescence STED) or by the use of mechanical force (Magnetic Tweezers, AFM). The equipment requested will be a hub of bespoke single molecule instrumentation, unique in the world, that will unveil the physical laws behind important biological questions. For example, capturing fleeting molecular processes; investigating the physical models that govern protein folding; characterising the phase behaviour of lipid membranes on sub-resolution length scales and investigating the role of lipids on a range of cellular processes.3. 'Ultrafast spectroscopy for Nano-, Bio- and Chemical imaging'The proposed facility provides a coherent and efficient platform dedicated to both the near and far-field non-linear optical characterization of nanostructured and biological materials and systems. A laser scanning microscope system will enable a simultaneous "multidimensional" characterization of these samples providing, in addition to polarization, spectral and angular resolution, information about processes below nanosecond timescales, and spatial resolutions of the order of the wavelength of light. The system will provide access to laser excitation with pules durations below 25 femtoseconds, providing a powerful pulsed optical excitation of samples. A pulsed white-light laser source will provide a source for a scanning near-field optical microscope to probe non-linear optical properties on the nanoscale.4. 'Tactile Internet'Driven by ultra-reliable & ultra-low delay networking technologies, along with developments in haptics and edge intelligence, the Internet as we know it will be dwarfed by the emergence of a to-date unprecedented Internet, the Tactile Internet. It will be able to deliver physical, tactile experiences remotely and invoke a fundamental shift from content-delivery to skillset-delivery networks. The equipment requested will create new networked autonomous robotic systems, combining telecommunications, robotics and AI planning. This unique combination will allow us to: explore unsolved problems in telecoms; test novel approaches to autonomous planning in geographically distributed production and service systems; test novel communication protocols of robotic remote proxies for haptic exploration of objects in a variety of sectors; test novel algorithms in remote servicing; test novel large-scale applications of AI planning and test the unique juxtaposition of communications, actuation and intelligence through the integration of all the above.

1.先进材料是BIS指定的八大技术之一，并被EPSRC标记为优先投资。反过来，光子学和纳米光子学是21世纪世纪最具渗透力的技术之一，对信息处理、太阳能收集、生物医学科学、安全传感等领域产生了影响。纳米光子学新的研究方向和新的应用的发展需要获得适当的纳米纤维和表征设备。该设施将联合收割机结合一系列最先进的仪器，用于制造超光滑和超光滑（< 1 nm）层和纳米结构及其表征，具有伦敦目前无法提供的功能。所要求的设备将加强目前在等离子体和纳米光子学方面的研究活动，同时开辟新的研究途径，如电子束诱导纳米光子学和纳米级量子光学。2.“单分子生物物理学和光子学”理解管理生命的物理机制一直是，现在仍然是，人类最重要的科学挑战之一。每个过程发生的分子机制在很大程度上仍然未知，因为它需要在很长一段时间内捕获单个分子的（通常是快速的）动态。单分子技术最近已经允许跟踪单个分子，或者通过使用光（例如，荧光STED）或通过使用机械力（磁性镊子，AFM）。所要求的设备将是世界上独一无二的定制单分子仪器的中心，它将揭示重要生物学问题背后的物理定律。例如，捕捉短暂的分子过程;研究控制蛋白质折叠的物理模型;在亚分辨率长度尺度上表征脂质膜的相行为，并研究脂质在一系列细胞过程中的作用。3.“用于纳米、生物和化学成像的超快光谱学”拟议的设施提供了一个连贯和高效的平台，致力于纳米结构和生物材料和系统的近场和远场非线性光学表征。激光扫描显微镜系统将使这些样品的同时提供“多维”表征，除了偏振，光谱和角度分辨率，有关纳秒时间尺度以下的过程的信息，以及光的波长的顺序的空间分辨率。该系统将提供脉冲持续时间低于25飞秒的激光激发，为样品提供强大的脉冲光激发。脉冲白光激光源将为扫描近场光学显微镜提供光源，以探测纳米尺度上的非线性光学特性。“触觉互联网”在超可靠和超低延迟网络技术的推动下，沿着触觉和边缘智能的发展，我们所知道的互联网将在前所未有的互联网触觉互联网的出现下相形见绌。它将能够远程提供物理和触觉体验，并引发从内容交付到技能交付网络的根本转变。所要求的设备将创建新的联网自主机器人系统，结合电信，机器人和人工智能规划。这种独特的组合将使我们能够：探索电信中未解决的问题;在地理分布的生产和服务系统中测试自主规划的新方法;测试机器人远程代理的新型通信协议，用于各种部门中对象的触觉探索;测试远程服务中的新算法;测试人工智能规划的新的大规模应用，并通过整合上述所有内容来测试通信，驱动和智能的独特并置。

项目成果

Nonlinear Goniometry by Second-Harmonic Generation in AlGaAs Nanoantennas

• DOI: 10.1021/acsphotonics.8b00810
• 发表时间: 2018-11-01
• 期刊: ACS PHOTONICS
• 影响因子: 7
• 作者: Carletti, Luca;Marino, Giuseppe;Neshev, Dragomir N.
• 通讯作者: Neshev, Dragomir N.

Assessing the Potential for Drug-Nanoparticle Surface Interactions To Improve Drug Penetration into the Skin.

评估药物-纳米颗粒表面相互作用改善药物渗透到皮肤的潜力。

• 发表时间: 2016
• 作者: []

Investigating the influence of drug aggregation on the percutaneous penetration rate of tetracaine when applying low doses of the agent topically to the skin

• DOI: 10.1016/j.ijpharm.2016.02.007
• 发表时间: 2016-04-11
• 期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS
• 影响因子: 5.8
• 作者: Cai, X. J.;Patel, T.;Jones, S. A.
• 通讯作者: Jones, S. A.

Tunable Ultra-high Aspect Ratio Nanorod Architectures grown on Porous Substrate via Electromigration.

• DOI: 10.1038/srep22272
• 发表时间: 2016-02-29
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Mansourian A;Paknejad SA;Wen Q;Vizcay-Barrena G;Fleck RA;Zayats AV;Mannan SH
• 通讯作者: Mannan SH

Spontaneous emission in non-local materials.

• DOI: 10.1038/lsa.2016.273
• 发表时间: 2017-06
• 期刊: Light, science & applications
• 作者: Ginzburg P;Roth DJ;Nasir ME;Segovia P;Krasavin AV;Levitt J;Hirvonen LM;Wells B;Suhling K;Richards D;Podolskiy VA;Zayats AV
• 通讯作者: Zayats AV