Engineering smart 3D silk fibroin tissue culture scaffolds using reactive inkjet printing
使用反应喷墨打印设计智能 3D 丝素蛋白组织培养支架
基本信息
- 批准号:EP/N007174/1
- 负责人:
- 金额:$ 12.65万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2015
- 资助国家:英国
- 起止时间:2015 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Population aging, increased diseases and unexpected accidents will result in huge demands of tissue/organ transplantation over the next decade. However, the demands are unlikely to be met due to the significant lack of donation and immune mismatching. The breakthrough of tissue engineering and regenerative medicine will offer remarkable success in building three-dimensional tissues suitable for transplantation. 3D porous scaffolds play important roles in tissue engineering not only as structural templates for tissue fabrication but also providing complex signaling cues to cells and facilitating oxygen and therapeutic agent delivery. Therefore, the availability of excellent 3D scaffolds has become one of the aspects that constrains the fast developing of tissue engineering. Production of excellent 3D scaffolds highly relies on i) suitable fabrication technology and ii) excellent candidate biomaterials. This first grant proposal seeks to harness the emerging additive manufacturing technology (reactive inkjet printing, RIJ) and the unique biomaterial (regenerated silk fibroin, RSF) for the fabrication of smart 3D tissue culture scaffolds. Silk fibroin (a FDA approved biomaterial) is well known for its good biocompatibility, biodegradability, and excellent mechanical properties, therefore, is an ideal candidate as scaffold for tissue engineering/regenerative medicine. Moreover, silk material is widely available worldwide as a cheap feedstock and is mostly used as low-tech/profit material in textile industry. There is plenty of room for exploiting silk as advanced material in high tech/profit industries. One of the applications that have attracted much attention is to develop biomaterials suitable for the fabrication of tissue scaffolds. However, the current RSF scaffolds made through traditional methods (e.g. casting, freeze-drying, electrospinning) have simple structures that are only suitable for lab research or very basic tissue engineering. A suitable manufacturing technology must be found for making advanced 3D scaffolds that provide more effective controls in micro scales. The advantages of RIJ are not only the computer assisted design (CAD) that offers the precise delivery of pico-litres (1e-12 litre) of ink at predetermined locations and that allows the fabrication of complex 3D architectures but also the alternate delivery of different inks (through different print heads) that allows the control of reactions during manufacturing and manipulation of the compositions and the properties of the scaffolds. Therefore, the combination of RSF material and the RIJ technology provide a promising opportunity for fabricating better 3D scaffolds for future regenerative medicine.
未来十年,人口老龄化、疾病增加和意外事故将导致对组织/器官移植的巨大需求。然而,由于严重缺乏捐赠和免疫错配,这些需求不太可能得到满足。组织工程和再生医学的突破将为构建适合移植的三维组织提供显著的成功。三维多孔支架在组织工程中发挥着重要的作用,不仅作为组织制造的结构模板,而且为细胞提供复杂的信号提示,促进氧气和治疗剂的传递。因此,能否获得优质的三维支架已成为制约组织工程快速发展的方面之一。优秀的3D支架的生产高度依赖于i)合适的制造技术和ii)优秀的候选生物材料。第一个拨款提案旨在利用新兴的增材制造技术(反应性喷墨打印,RIJ)和独特的生物材料(再生丝素,RSF)来制造智能3D组织培养支架。丝素蛋白(FDA批准的生物材料)以其良好的生物相容性、生物可降解性和优异的机械性能而闻名,是组织工程/再生医学中理想的支架材料。此外,丝绸作为一种廉价的原料在世界范围内广泛使用,在纺织工业中主要用作低技术/利润的材料。丝绸作为高科技/利润行业的先进材料有很大的开发空间。其中一个备受关注的应用是开发适合于制造组织支架的生物材料。然而,目前通过传统方法(如铸造、冷冻干燥、静电纺丝)制成的RSF支架结构简单,仅适用于实验室研究或非常基础的组织工程。必须找到合适的制造技术来制造先进的3D支架,以便在微观尺度上提供更有效的控制。RIJ的优势不仅在于计算机辅助设计(CAD),它可以在预定的位置提供精确的皮升(1e-12升)墨水,允许制造复杂的3D结构,而且还可以通过不同的打印头交替提供不同的墨水,从而可以控制制造过程中的反应和操纵支架的成分和性能。因此,RSF材料和RIJ技术的结合为未来再生医学制造更好的3D支架提供了一个有希望的机会。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Altering the Bubble Release of Reactive Inkjet Printed Silk Micro-rockets
- DOI:10.2352/issn.2169-4451.2017.32.452
- 发表时间:2016-09
- 期刊:
- 影响因子:0
- 作者:D. Gregory;Y. Zhang;Patrick J. Smith;S. Ebbens;Xiubo Zhao
- 通讯作者:D. Gregory;Y. Zhang;Patrick J. Smith;S. Ebbens;Xiubo Zhao
Designed Antitumor Peptide for Targeted siRNA Delivery into Cancer Spheroids
- DOI:10.1021/acsami.1c14761
- 发表时间:2021-10-18
- 期刊:
- 影响因子:9.5
- 作者:Cirillo, Silvia;Tomeh, Mhd Anas;Zhao, Xiubo
- 通讯作者:Zhao, Xiubo
Reactive Inkjet Printing and Propulsion Analysis of Silk-based Self-propelled Micro-stirrers.
丝基自驱动微搅拌器的反应喷墨打印和推进分析。
- DOI:10.3791/59030
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Gregory DA
- 通讯作者:Gregory DA
Reactive Inkjet Printing: Reactive Inkjet Printing of Biocompatible Enzyme Powered Silk Micro-Rockets (Small 30/2016)
反应喷墨印刷:生物相容性酶驱动丝微火箭的反应喷墨印刷(小30/2016)
- DOI:10.1002/smll.201670148
- 发表时间:2016
- 期刊:
- 影响因子:13.3
- 作者:Gregory D
- 通讯作者:Gregory D
Surfactant like peptides for targeted gene delivery to cancer cells.
- DOI:10.1016/j.bbrc.2023.02.026
- 发表时间:2023-02
- 期刊:
- 影响因子:3.1
- 作者:Roja Hadianamrei;Mhd Anas Tomeh;Jiqian Wang;Stephen Brown;Xiubo Zhao
- 通讯作者:Roja Hadianamrei;Mhd Anas Tomeh;Jiqian Wang;Stephen Brown;Xiubo Zhao
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Xiubo Zhao其他文献
An enzyme-responsive double-locked amonafide prodrug for the treatment of glioblastoma with minimal side effects
一种对酶敏感的双锁氨莫司汀前药用于治疗胶质母细胞瘤且副作用最小
- DOI:
10.1039/d4sc04555f - 发表时间:
2024-10-25 - 期刊:
- 影响因子:7.400
- 作者:
Wei Cheng;Yanli Yang;Bo Zhang;Chen-Wen Shao;Wei Chen;Ruimin Xia;Wenwei Sun;Xiubo Zhao;Bing Zhang;Xiangjie Luo;Tony D. James;Yong Qian - 通讯作者:
Yong Qian
Rationally designed short cationic α-helical peptides with selective anticancer activity
具有选择性抗癌活性的合理设计的短阳离子α-螺旋肽
- DOI:
10.1016/j.jcis.2021.08.200 - 发表时间:
2022-02-01 - 期刊:
- 影响因子:9.700
- 作者:
Roja Hadianamrei;Mhd Anas Tomeh;Stephen Brown;Jiqian Wang;Xiubo Zhao - 通讯作者:
Xiubo Zhao
3D culture of fibroblasts and neuronal cells on microfabricated free-floating carriers.
在微型自由浮动载体上进行成纤维细胞和神经元细胞的 3D 培养。
- DOI:
10.1016/j.colsurfb.2023.113350 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Piyush Kumar;Ana Jimenez Franco;Xiubo Zhao - 通讯作者:
Xiubo Zhao
Plasmid DNA complexation with phosphorylcholine diblock copolymers and its effect on cell transfection.
质粒 DNA 与磷酸胆碱二嵌段共聚物的复合及其对细胞转染的影响。
- DOI:
- 发表时间:
2008 - 期刊:
- 影响因子:3.9
- 作者:
Xiubo Zhao;Zhuoqi Zhang;F. Pan;T. Waigh;J. Lu - 通讯作者:
J. Lu
Structural Insight of Antibody Adsorption for Improved Bioactivity and Detection
抗体吸附的结构洞察以改善生物活性和检测
- DOI:
10.1021/bk-2012-1120.ch025 - 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
Xiubo Zhao;M. Yaseen;F. Pan;J. Lu - 通讯作者:
J. Lu
Xiubo Zhao的其他文献
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{{ truncateString('Xiubo Zhao', 18)}}的其他基金
Fabrication of antibody functionalized silk fibroin micro-well arrays using reactive inkjet printing for circulating tumour cell capture
使用活性喷墨打印制备抗体功能化丝素蛋白微孔阵列以捕获循环肿瘤细胞
- 批准号:
EP/N023579/1 - 财政年份:2016
- 资助金额:
$ 12.65万 - 项目类别:
Research Grant
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- 批准号:20Y11906600
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