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Mapping and controlling nucleation

映射和控制成核

基本信息

批准号：
EP/N007417/1
负责人：
Klaas Wynne
金额：
$ 53.67万
依托单位：
University of Glasgow
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FN007417%2F1
关键词：
Mapping controlling nucleation

项目摘要

The nucleation of a new phase from solution, such as the nucleation of crystals, is of immense importance to both industry and fundamental science. Industrial crystallisation has changed little in the past 350 years and suffers from an embarrassing lack of control with sometimes unexpected and severe financial consequences. Unfortunately, the theoretical understanding of crystal nucleation has not improved much since the work of Ostwald and Gibbs a century ago. Exceptions are the work by Cölfen on non-classical nucleation theories and that of Frenkel, on the role of critical density fluctuations in crystallisation. However, these new ideas are often applied within chemical engineering without a real understanding of the applicability of the underlying chemical physics.Here it is proposed to map and control the early stages of nucleation in liquids. Nucleation will be treated in its most general form, that is, liquid-gas, liquid-liquid, and liquid-solid, while taking into consideration the possible presence of liquid-liquid critical points. Driving these systems very far from equilibrium, will allow us to create meta- and unstable states that will give rise to nucleation and spinodal decomposition. The subsequent highly non-equilibrium processes will be mapped using transmitted-light and Raman microscopy and, in particular, fluorescence microscopy using a range of environmentally sensitive fluorophores. We propose to develop a novel instrument that will change the study of crystal nucleation and will make the first steps towards control over the polymorph that crystallises. It involves laser-induced nucleation using powerful picosecond and femtosecond lasers, and programmable diffractive optics, resulting in a massively parallel nucleation set-up. The resultant nucleation events will be followed in real-time using the mapping techniques developed previously. This breakthrough will allow us to carry out very large numbers of experiments and collect meaningful statistics for the first time. The massively parallel nucleation instrument will be used to carry out a number of nucleation-control experiments ranging from the relatively straightforward nucleation of liquid-crystalline phases or bubbles, to the induction of chirality in nucleation using "massively parallel optical stirrer beans" employing the spin and orbital angular momentum of light.

溶液中新相的成核，如晶体的成核，对工业和基础科学都具有极其重要的意义。在过去的350年里，工业结晶化几乎没有改变，并且由于缺乏控制而令人尴尬，有时会产生意想不到的严重财务后果。不幸的是，自世纪前Ostwald和Gibbs的工作以来，晶体成核的理论认识并没有多大改进。这是工作的科尔芬对非经典的成核理论和弗伦克尔，对作用的临界密度波动结晶。然而，这些新的想法往往被应用在化学工程中，没有真实的理解的基础化学物理的适用性。在这里，它提出了映射和控制成核的早期阶段的液体。成核将以其最一般的形式，即液-气、液-液和液-固进行处理，同时考虑可能存在的液-液临界点。驱动这些系统远离平衡，将使我们能够创造Meta和不稳定的状态，这将引起成核和旋节分解。随后的高度非平衡过程将映射使用透射光和拉曼显微镜，特别是荧光显微镜使用一系列的环境敏感的荧光团。我们建议开发一种新的仪器，将改变晶体成核的研究，并将使第一步控制多晶型结晶。它涉及使用强大的皮秒和飞秒激光器的激光诱导成核，以及可编程衍射光学器件，从而产生大规模并行成核设置。将使用先前开发的映射技术实时跟踪所产生的成核事件。这一突破将使我们能够进行大量的实验，并首次收集有意义的统计数据。大规模并行成核仪器将用于进行一些成核控制实验，范围从相对简单的液晶相或气泡的成核，到使用“大规模并行光学搅拌豆”采用光的自旋和轨道角动量的成核中的手性诱导。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Low-frequency vibrational modes in G-quadruplexes reveal the mechanical properties of nucleic acids.

DOI：
10.1039/d0cp05404f
发表时间：
2021-06-21
期刊：
Physical chemistry chemical physics : PCCP
影响因子：
0
作者：
González-Jiménez M ;Ramakrishnan G ;Tukachev NV ;Senn HM ;Wynne K
通讯作者：
Wynne K

Understanding the emergence of the boson peak in molecular glasses.

DOI：
10.1038/s41467-023-35878-6
发表时间：
2023-01-13
期刊：
NATURE COMMUNICATIONS
影响因子：
16.6
作者：
Gonzalez-Jimenez, Mario;Barnard, Trent;Russell, Ben A.;Tukachev, Nikita V.;Javornik, Uros;Hayes, Laure-Anne;Farrell, Andrew J.;Guinane, Sarah;Senn, Hans M.;Smith, Andrew J.;Wilding, Martin;Mali, Gregor;Nakano, Motohiro;Miyazaki, Yuji;McMillan, Paul;Sosso, Gabriele C.;Wynne, Klaas
通讯作者：
Wynne, Klaas

Characterisation of the Boson Peak from the Glass into the Liquid

从玻璃到液体的玻色子峰的表征