Clinical Outcomes with Electroconvulsive Therapy: Insights from Computational Modelling

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Electroconvulsive therapy (ECT) is the treatment of choice for severe, resistant depression. However it use is reduced by concerns about memory problems. The effectiveness and side effects of ECT depend on how it is given, but clinical trials can only test 1 variation at a time. This study will use sophisticated computational modelling to understand how varying the treatment approach affects clinical outcomes, allowing the development of next-generation, custom-designed ECT treatment.