MECHANISMS OF BILE FORMATION

活体动物、灌流器官、分离细胞和人造 膜被用来探索胆汁形成的生理学 基础水平上的肝脏溶质转运。有一个 非常重视生物物理技术、数学 通过建模和计算机仿真来实现这些目标。 长期的目标是了解这种疾病的发病机制。 胆汁淤积症和胆石症对人类的影响 这些疾病对正常排泄和代谢的影响 内源性产物，如胆红素、胆汁酸和长链脂肪 并阐明肝药的药代动力学。 处理完了。更直接的目标是设计和验证 测定肝脏转运速率常数的新方法 为了揭开肝脏如何有效地处理 到达传入循环的有机溶质将被 血浆蛋白。

Live animals, perfused organs, isolated cells, and artificial membranes are used to explore the physiology of bile formation and hepatic solute transport at a fundamental level. There is a strong emphasis on biophysical techniques, mathematical modeling, and computer simulation to achieve these objectives. The long term goal is to understand the pathogenesis of such human afflictions as cholestasis and cholelithiasis, the effect of these diseases on the normal excretion and metabilism of endogenous products like bilirubin, bile acids, and long chain fatty acids and to elucidate the pharmacokinetics of hepatic drug disposal. More immediate objectives are to devise and validate new ways to measure the rate constants for hepatic transport and to unravel the mystery of how the liver deals efficiently with organic solutes that arrive in the afferent circulation bound to plasma proteins.