MECHANISMS OF BILE FORMATION

活体动物、灌注器官、分离细胞和人工 膜用于探索胆汁形成的生理学 和肝脏溶质转运的基础水平。 有一个 强调生物物理技术、数学 建模和计算机模拟来实现这些目标。 长期目标是了解这种疾病的发病机制， 人类的痛苦，如胆汁淤积和胆石症， 这些疾病对正常排泄和代谢的影响 内源性产物如胆红素、胆汁酸和长链脂肪酸， 并阐明肝脏药物的药代动力学 处置 更直接的目标是设计和验证 测量肝脏转运速率常数的新方法， 来揭开肝脏如何有效处理 进入传入循环的有机溶质 血浆蛋白

Live animals, perfused organs, isolated cells, and artificial membranes are used to explore the physiology of bile formation and hepatic solute transport at a fundamental level. There is a strong emphasis on biophysical techniques, mathematical modeling, and computer simulation to achieve these objectives. The long term goal is to understand the pathogenesis of such human afflictions as cholestasis and cholelithiasis, the effect of these diseases on the normal excretion and metabilism of endogenous products like bilirubin, bile acids, and long chain fatty acids and to elucidate the pharmacokinetics of hepatic drug disposal. More immediate objectives are to devise and validate new ways to measure the rate constants for hepatic transport and to unravel the mystery of how the liver deals efficiently with organic solutes that arrive in the afferent circulation bound to plasma proteins.