SPHERICAL MONODISPERSED MAGNETIZABLE RESIN LATICES

我们的主要目标是制备小的单分散树脂乳液，这可能是 被外部磁场放大的。立即应用于 这种材料--在与合适的抗体偶联后--就是核磁共振图像 用于癌症或癌症转移早期检测的造影剂 它们太小而不能用目前的方法检测。要做到这一点 目标，可磁化无机氧化物在苯乙烯中的分散体 在不同水平的表面活性剂存在下聚合以控制 颗粒大小，并在几种功能单体中的一种存在时 增强与蛋白质共价结合的能力。涂层的效果 将对具有惰性聚合物外壳的可磁化粒子进行评估。 我们在第一阶段的具体目标是提供所示的材料。它的 考虑将其作为诊断工具进行商业开发的潜力 太棒了。此外，该项目将导致产品具有多种 颗粒直径，这将在其他方面找到应用。已经有一个 关于可磁化粒子的新应用的报告数量。我们的 产品将是新颖的，因为它们不是永久磁化的，是 单一分散的。它们将基于合成化合物，这些化合物可能是 经修饰后可与抗体共价结合。

Our chief aim is to prepare small monodispersed resin latices which may be magnitized by an external magnetic field. The immediate application of such material - after coupling to suitable antibodies - is as NMR image contrasting agents for the early detection of cancer or cancer metastasis which are too small for detection by present methods. To achieve this goal, dispersions of magnetizable inorganic oxides in styrene are to be polymerized in the presence of varying levels of surfactants to control particle size and in the presence of one of several functional monomers to enhance capability to bond covalently to proteins. The effect of coating magnetizable particles with shells of inert polymers will be evaluated. Our specific aim under Phase I is to provide materials as indicated. Its potential for commercial development as a diagnostic tool is considered great. In addition, this project will lead to a product with a variety of particle diameters which will find other applications. There already are a number of reports on novel applications of magnetizable particles. Our products will be novel because they are not permanently magnetized, are monodispersed. They will be based on synthetic compounds which may be modified for covalent bonding to antibodies.