FISH OILS AS CARDIOVASCULAR AGENTS

鱼油作为心血管药物

• 批准号: 3500881
• 负责人: BARRY D SEARS
• 金额: $ 3.31万
• 依托单位: PGE TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-15 至 1987-02-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3500881
• 关键词: Lepidoptera; antioxidants; cardiovascular agents; cardiovascular disorder prevention; chemical stability; eicosanoids; food additives; marine animal oil; nutrition related tag; omega 3 fatty acid; phospholipids; saltwater environment; surfactant

Studies in the medical literature since the 1970's have strongly suggested that eicosapentaenoic acid (EPA) is a significant modulator of thromboxane and prostaglandin activity, primarily in its role as a precursor of the "3" class of thromboxanes and prostaglandins. Recently a 20-year epidemiological study uncovered a strong correlation between increased fish consumption and decreased cardiovascular disease mortality in a Dutch population. A diet containing greater than 400 mg per day of EPA gave greater than a 50% reduction in cardiovascular disease mortatlity, compared with a diet containing no fish oil. It appears possible from this and other studies that relatively low intake of EPA-rich oils on a chronic basis may substantially reduce the risk of cardiovascular mortality. PGE Technology has recently processed a fish oil to contain 30% EPA without heavy metal or PCB contamination. The major obstacle to approval of this oil as a pharmaceutical is its instability to oxidation. Phase I research will focus on stabilizing EPA-rich oils using tocopherols and a new class of semi-synthetic phospholipids, the Lipid X surfactants. These surfactants are unique in being completely miscible with oils, and so will solubilize the tocopherols. If the resistance to oxidation can be raised to greater than an ACM of 8 hours, Phase II studies would include toxicology studies of Lipid X administered orally to animals, with a goal of obtaining FDA approval of Lipid X as a food additive.

自 20 世纪 70 年代以来的医学文献研究强烈表明 二十碳五烯酸 (EPA) 是血栓素的重要调节剂 和前列腺素活性，主要在于其作为“3”的前体的作用 血栓素和前列腺素类。 最近20年 流行病学研究发现鱼类数量增加之间存在很强的相关性 荷兰人的消费量和心血管疾病死亡率的降低 人口。 每天含有超过 400 毫克 EPA 的饮食可以产生 相比之下，心血管疾病死亡率降低了 50% 以上 饮食不含鱼油。 由此看来有可能 其他研究表明，慢性病患者摄入富含 EPA 的油相对较少。 基础可能会大大降低心血管死亡的风险。 PGE Technology 最近加工出一种鱼油，其中含有 30% EPA，且不含 重金属或 PCB 污染。 此次批准的主要障碍 油作为药物是其对氧化的不稳定性。 一期研究 将专注于使用生育酚和新类别来稳定富含 EPA 的油 半合成磷脂，Lipid X 表面活性剂。 这些 表面活性剂的独特之处在于与油完全混溶，因此 溶解生育酚。 如果可以提高抗氧化能力 超过 8 小时的 ACM，II 期研究将包括 动物口服脂质 X 的毒理学研究，目标是 获得 FDA 批准 Lipid X 作为食品添加剂。