空心粘膜假体的设计和评估-猫眼课题宝

空心粘膜假体的设计和评估

批准号：

3495579

负责人：

RICHARD E HOFFER

金额：

$4.73万

依托单位：

DESERET RESEARCH COMPANY

依托单位国家：

美国

项目类别：

财政年份：

1986

资助国家：

美国

项目状态：

已结题

起止时间：

1986-08-01 至 1987-03-31

来源：

https://reporter.nih.gov/project-details/3495579

关键词：

biomaterial development /preparation biomaterial evaluation biomaterial interface interaction biomaterials biotransformation electron microscopy histology intestinal mucosa intestine surgery microscopy polyurethanes prosthesis silicone rubber tissue support frame wound healing

中文摘要

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英文摘要

This proposed study is designed to develop and evaluate a method of replacing a hollow viscus with a prosthesis that allows primary mucosal healing and incorporation of the prosthetic into the healing process. Healing of a full thickness isolated bowel segment to 2 types of a hollow viscus prosthesis will be evaluated in dogs. Both types of prosthesis will consist of an outer rigid mesh and a biodegradable middle layer. The Type A prosthesis will have an inner impervious layer; the Type B prosthesis will not. The prostheses will be evaluated at various post-implantation times of up to and including 60 days. Evaluation of healing patterns of the prostheses and mucosal regeneration, infection, connective tissue ingrowth, rejection and stricture by gross light and electron microscopy will be performed.

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