DESIGN AND EVALUATION OF A COMPOUND TRACHAEL PROSTHESIS

拟议的研究旨在开发和评估一种方法 用一种复合假体取代气管，这将是 颊组织培养种植时上皮化的研究 粘膜或气管粘膜的游离移植物。伤口的愈合 将对两种类型的颈段气管假体进行评估 狗。这两种类型都将有一个硬质聚乙烯外层和一个 动脉粥样硬化胶原的中间层。内层或类型1 假体将由口腔粘膜组织培养到 胶原层。II型假体将有一个自由移植的 气管粘膜。假体将在不同的地方进行评估 植入后时间长达60天。对该计划的评估 移植和培养粘膜愈合的手术部位， 增殖、结缔组织生长、疤痕形成、感染和 拒收将通过肉眼检查和 从组织病理学上看。

The proposed study is designed to develop and evaluate a method of replacing the trachea with a compound prosthesis that will be epithelized at the time of implantation by tissue culture of buccal mucosa or a free graft of tracheal mucosa. Healing of the cervical trachea to two types of prosthesis will be evaluated in dogs. Both types will have a rigid polyethylene outer layer and a middle layer of atherocollagen. The inner layer or Type 1 prosthesis will consist of buccal mucosal tissue cultured onto the collagen layer. The Type 2 prosthesis will have a free graft of tracheal mucosa. The prostheses will be evaluated at various post-implantation times of up to 60 days. Evaluation of the surgical sites for grafted and cultured mucosal healing, proliferation, connective tissue growth, scarring, infection, and rejection will be performed by gross examination and histopathologically.