LASER CATHETER ULTRASONIC IMAGING SYSTEM

这个项目的目标是开发一种原型导管- 一种可用于激光定向的安装式超声换能器 使用通过光纤传输的光的外科手术 导尿管。激光手术可以精确地消融病变，如 肿瘤、动脉粥样硬化斑块和血管畸形 其他技术无法访问的站点。然而，它是 也相对容易损伤邻近或的正常组织 在病变下面，或在空洞中造成穿孔 结构。这些并发症可以在原位手术中避免。 有关字符和厚度的诊断信息 靶组织及其引起的热变性程度 激光能量。超声波成像(即使是简单的，一- Dimensional)更有可能提供此信息 光学或放射技术。这一阶段的具体目标 我的建议是建造和评估一个微型的，超声波 分辨率低于100微米的传感器和 成像深度小于1厘米，可与 侧面发射光纤以确定病变厚度和 控制消融。传感器将在模型系统中进行测试 以及在体外的动物和人类组织中。

The goal of this project is to develop a prototype catheter- mounted ultrasonic transducer which could be used to direct laser surgery procedures which use light delivered through fiber optic catheters. Laser surgery allows precise ablation of lesions such as tumors, atherosclerotic plaques and vascular malformations at sites which are inaccessible by other techniques. However, it is also relatively easy to damage normal tissues adjacent to or underlying the lesions, or to cause perforations in hollow structures. These complications might be avoided with in situ diagnostic information about the character and thickness of the target tissue and the extent of thermal denaturation caused by the laser energy. Ultrasonic imaging (even simple, one- dimensional) is more likely to provide this information than are optical or radiological techniques. The specific aims of this Phase I proposal are to construct and evaluate a miniature, ultrasonic transducer with a resolution of less than 100 micron and an imaging depth less than 1 cm which could be combined with a side-emitting optical fiber to determine lesion thickness and control ablation. The transducer will be tested in model systems and in animal and human tissues in vitro.