MINIATURE RADFETS--RADIOIMMUNO/BRACHYTHERAPY DOSIMETRY

微型辐射场--放射免疫/近距离治疗剂量测定

• 批准号: 2104142
• 负责人: WILLIAM H NEWMAN
• 金额: $ 7.5万
• 依托单位: THERMAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-20 至 1995-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2104142
• 关键词: biomedical equipment development; neoplasm /cancer radionuclide therapy; patient monitoring device; radiation dosage; semiconduction

This project will address the need for real-time, continuous measurement of radiation dose in vivo. Single- and dual-dielectric radiation sensing field effect transistor (RADFET) fabrication sequences will be developed. A mask set for semiconductor processing will be designed and manufactured. These masks will be used to fabricate both isolated transistors and arrays of RADFETs of both types for evaluation and optimization of the process as well as characterization of the sensors. The process will be incorporated into an integrated circuit fabrication sequence so that RADFETs and circuits can be manufactured on a single silicon substrate. Smart radiation sensors, containing a sensor as well as excitation, control and analog to digital conversion will be developed under Phase II. These chips will be assembled into a multisite, digital output probe. Each year close to l million new cases of cancer are reported in the US alone; nearly 60% or 600,000 of those cases are treated with radiation. Radioimmunoassay therapy (RIT) is currently under investigation and in clinical trials as a novel technique of targeting tumors. The instrument will allow real time dose rate and total accumulated dose measurements during RIT treatment. This information, unobtainable by any current techniques, will result in better pre-treatment planning and post-treatment evaluation as well as potential optimization of radiation exposure during radioimmunotherapy. In addition, the small RADFET sensors can be used for brachytherapy stereotactic radiotherapy and on-patient monitoring.

该项目将满足实时、连续 测量体内辐射剂量。单介质和双介质 辐射敏感场效应晶体管的制造 序列将被开发。一种用于半导体的掩模组， 加工将设计和制造。这些面具将 用于制造隔离晶体管和RADFFET阵列 这两种类型的评估和优化的过程， 以及传感器的特性。这个过程将是 结合到集成电路制造序列中， RADFFET和电路可以在单个硅上制造， 衬底智能辐射传感器，包含传感器以及 励磁、控制和模数转换将 在第二阶段开发。这些芯片将被组装成一个 多位数字输出探头。 每年有近100万新的癌症病例报告， 仅在美国;近60%或600，000例病例接受治疗， 辐射放射免疫疗法（RIT）目前正在 研究和临床试验中作为一种新技术， 靶向肿瘤。仪器将允许真实的时间剂量率， RIT治疗期间的总累积剂量测量。这 信息，无法通过任何现有技术，将导致 更好的治疗前计划和治疗后评估 作为辐射暴露的潜在优化， 放射免疫疗法此外，小型RADFET传感器可以 用于近距离放射治疗立体定向放射治疗和患者 监测.