DRUG DESIGN FOR THE TREATMENT OF BLADDER INCONTINENCE
DRUG DESIGN FOR THE TREATMENT OF BLADDER INCONTINENCE
治疗膀胱失禁的药物设计
批准号：
3487827
负责人：
EDWARD JAKOBOVITS
金额：
$5.0万
依托单位：
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
项目状态：
已结题
起止时间：
1989-08-01 至 1990-01-31
关键词：
drug design /synthesis /production immunocytochemistry in situ hybridization inhibitor /antagonist ion exchange chromatography laboratory rabbit molecular cloning muscarinic receptor nervous system disorder chemotherapy nucleic acid sequence radioimmunoassay receptor binding receptor expression stimulant /agonist synthetic nucleic acid tissue /cell culture transfection transposon /insertion element urinary incontinence western blottings
中文摘要
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英文摘要
Bladder incontinence is a functional disorder with growing consequences
for the aging population. Current therapy includes drug treatment aimed
at antagonizing the cholinergic input to the bladder. There are severe
drawbacks to drug therapy primarily due to the lack of specificity of
the drugs which result in side effects, many of which cannot be
tolerated by the elderly.
We propose to design novel pharmaceutica agents which are both
efficacious and highly specific. Using rDNA technologies we will design
peptomementic molecules which reconstruct specific sites of receptor
interaction with cellular metabolic machinery and, as a result, mimic
receptor action. This will provide a new approach for the rational
design of more specific drugs to address problems of the autonomic
nervous system.
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