Complex ORAL health products (CORAL): Characterisation, modelling and manufacturing challenges

复杂口腔保健产品 (CORAL)：表征、建模和制造挑战

• 批准号: EP/N024915/1
• 负责人: Panagiota Angeli
• 金额: $ 247.95万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN024915%2F1
• 关键词: Complex; ORAL; health; products; CORAL

Toothpastes - and especially specialised pharmaceutical toothpastes, whose major gel component is not water-based - have a surprisingly complex and ill-understood manufacturing process. There is the background fluid, which is already a mixture of a viscous liquid and a polymer; then solid particles are added. These are abrasive and do much of the tooth cleaning; but they also swell during processing, and the system becomes much thicker when they are added. Finally surfactant is added to help the toothpaste to foam in the mouth; and just to complicate matters further, air bubbles also creep in during processing. In this project, we will systematically address all the stages of toothpaste processing. We will carry out precise small-scale rheological measurements to discover how the particles swell and how they interact once they have swollen: for example, do they absorb parts of the long polymer molecules to form a network, or do partly-absorbed polymers act as "brushes" to push swollen particles apart? We will also measure the overall behaviour of each stage of the system (the background fluid on its own, or with particles, or with bubbles) and create a phase map of system behaviour in terms of its composition. We will use advanced mathematical modelling techniques to derive new equations that can describe the behaviour of a mixture - for example, background fluid and swollen particles - as if it were a single material. Finally, we will use our new constitutive equations in computer simulations to predict the behaviour of the paste in a real processing environment, address the manufacturing challenges such novel formulations entail and propose new strategies to overcome these.The research needs a team with many different specialist abilities, across experimentation, modelling and simulation, and also needs close ties with industry to ensure we are asking the right questions. GSK is a major collaborator on this project. The project is also supported by Xaar the leader in inkjet printing technology. With the understanding we generate, they hope to make their manufacturing processes both more efficient and more reliable and also develop new formulations to address future customer needs.

牙膏 - 尤其是专门的药品牙膏，其主要凝胶成分不是水性的 - 具有令人惊讶的复杂且不理解的制造工艺。有背景流体，它已经是粘性液体和聚合物的混合物。然后添加固体颗粒。这些是磨碎的，并且要大部分清洁牙齿。但是它们在处理过程中也膨胀，并且添加时系统会变得更厚。最后，添加表面活性剂以帮助牙膏在口腔中泡沫。只是为了使事情变得更复杂，在处理过程中，气泡也会蔓延。在这个项目中，我们将系统地解决牙膏处理的所有阶段。我们将进行精确的小规模的流变学测量，以发现颗粒肿胀后颗粒如何膨胀以及它们如何相互作用：例如，它们是否吸收了长聚合物分子的一部分以形成网络，或者进行部分吸收的聚合物作为“刷子”作为“刷子”，以将鼻子分开？我们还将测量系统的每个阶段的总体行为（本身是背景流体，颗粒或带有气泡），并根据其组成而创建系统行为的相位图。我们将使用先进的数学建模技术来得出可以描述混合物行为的新方程，例如背景流体和肿胀颗粒，就好像它是一种材料一样。最后，我们将在计算机模拟中使用新的本构方程来预测糊状物在真实处理环境中的行为，应对制造业的挑战，这些新颖的配方需要并提出新的策略来克服这些策略。研究需要一个具有许多不同专家能力的团队，在实验，建模和模拟中都需要与行业进行密切的联系，以确保我们提出正确的问题。 GSK是该项目的主要合作者。该项目还得到了喷墨印刷技术领导者Xaar的支持。有了我们的理解，他们希望使制造过程更加高效，更可靠，并开发新的配方以满足未来的客户需求。

项目成果

Experimental insights into elasto-inertial transitions in Taylor-Couette flows.

• DOI: 10.1098/rsta.2022.0131
• 发表时间: 2023-03-20
• 期刊: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
• 影响因子: 5
• 作者: Boulafentis, T.;Lacassagne, T.;Cagney, N.;Balabani, S.
• 通讯作者: Balabani, S.

Table Salt as a Template to Prepare Reusable Porous PVDF-MWCNT Foam for Separation of Immiscible Oils/Organic Solvents and Corrosive Aqueous Solutions

• DOI: 10.1002/adfm.201702926
• 发表时间: 2017-11-03
• 期刊: ADVANCED FUNCTIONAL MATERIALS
• 影响因子: 19
• 作者: Chen, Faze;Lu, Yao;Parkin, Ivan P.
• 通讯作者: Parkin, Ivan P.

Influence of Shear-Thinning Rheology on the Mixing Dynamics in Taylor-Couette Flow

• DOI: 10.1002/ceat.201900015
• 发表时间: 2019-08-01
• 期刊: CHEMICAL ENGINEERING & TECHNOLOGY
• 影响因子: 2.1
• 作者: Cagney, Neil;Balabani, Stavroula
• 通讯作者: Balabani, Stavroula

Taylor-Couette flow of polymer solutions with shear-thinning and viscoelastic rheology

• DOI: 10.1017/jfm.2020.701
• 发表时间: 2020-12-25
• 期刊: JOURNAL OF FLUID MECHANICS
• 影响因子: 3.7
• 作者: Cagney, Neil;Lacassagne, Tom;Balabani, Stavroula
• 通讯作者: Balabani, Stavroula

Stability estimate for scalar image velocimetry

标量图像测速的稳定性估计

• DOI: 10.1515/jiip-2020-0107
• 发表时间: 2023
• 期刊: Journal of Inverse and Ill-posed Problems
• 影响因子: 1.1
• 作者: Burman E