MAGNETIC GELATIN PARTICLES FOR TUMOR DETECTION

此第一阶段SBIR提案的目的是开发3微米 结合使用时用于肿瘤检测的稳定微泡 超音波。这项提议建立在微泡技术的基础上， 起源于1976年，由国际和平协会发起，从那时起一直持续到现在。 明胶包裹的微泡附着在异常的血管壁上。 因为气泡起到超声波反射器的作用，所以少量的 临床超声可以观察到微泡，并希望 它们在检测小肿瘤方面将是有效的。这样的泡沫表现为 作为部位特异性肿瘤标记物与肿瘤血管壁结合 长达15分钟，但进入正常组织的微泡溶解并 几分钟内就可以清理完毕。为了给临床医生提供一些控制 在微泡上，一种生物相容的氧化铁，能够 被磁铁取代，将被添加到气泡壁上。因此， 使用超声波，临床医生可以在水下观察起泡剂 磁制导，以便将它们集中在目标区域。 拟议的第一阶段工作的主要目标是形成泡沫 能够产生3微米明胶胶囊微泡的发生器。 第二阶段的活动将旨在量化和优化 植入性和自发性肿瘤的体内技术。

The purpose of this Phase I SBIR proposal is to develop a 3 micron stabilized microbubble for tumor detection when used in conjunction with ultrasound. This proposal builds on a microbubble technology that originated in 1976 by the PI and has continued since that time. Gelatin encapsulated microbubbles adhere to abnormal vessel walls. Because bubbles act as ultrasonic reflectors, small quantities of microbubbles can be visualized with clinical ultrasound, and it is hoped that they will be effective in detecting small tumors. Such bubbles act as site-specific tumor markers when they adhere to tumor vessel walls for up to 15 minutes, but microbubbles entering normal tissue dissolve and clear in minutes. In order to provide the clinician with some control over the microbubbles, a biocompatible iron oxide, which is capable of being displaced by a magnet, will be added to the bubble wall. Thus, using ultrasound, the clinician can observe the bubble agents while under magnetic guidance in order to concentrate them in the target area. The primary goal of the proposed Phase I effort is to develop a bubble generator capable of producing 3 micron gelatin encapsulated microbubbles. Phase II activities will be aimed at quantification and optimization of the technique in vivo with implanted and spontaneous tumors.