MAGNETIC GELATIN PARTICLES FOR TUMOR DETECTION

明胶包裹的微管(GEM)黏附于肿瘤血管壁 时间段最长可达10分钟。因为气泡具有很强的回声 对于超声波，它们充当超声波反射器，识别 肿瘤的血管系统。正常的血管能迅速清除气泡。因此，这就是 两者之间的时间延迟允许肿瘤的分离和定位。 由于气泡具有很强的回声能力，人们希望它们能被用来 辨别小肿瘤。一期工程研制出3微米宝石 能清除肺部进入全身的微粒 发行量。为了增加进入的粒子数量 总面积，磁铁矿，磁性氧化铁，已添加到 内墙。因此，临床医生可以引导粒子进入普通的 并增加了当地的人口和回声。 第二阶段研究的主要目标是证明 活体内的概念。该试剂将在肿瘤模型和其他模型上进行测试 狗和猫的自发性肿瘤。遵循以下优化 将开发粒子方法来评估各种类型的 使用小鼠模型进行癌症研究。这项技术的目的是检测 小肿瘤的时候治愈的可能性最大。

Gelatin Encapsulated Microtubules (GEM) adhere to tumor vessel walls for periods of time up to 10 minutes. Because bubbles are highly echogenic to ultrasound, they act as ultrasonic reflectors and identify the vasculature of tumors. Normal vessels clear bubbles quickly. Thus this time lag between the two permits separation and localization of tumors. Because bubbles are so echogenic, it is hoped that they can be used to identify small tumors. Phase I program developed a 3 micron GEM microparticle capable of clearing the lungs to enter the systemic circulation. In order to increase the number of particles entering a general area, magnetite, magnetic iron oxide, has been added to the inner wall. Thus the clinician can steer particles entering a general area and increase the local population and echogenicity. The primary goal of Phase II studies is to demonstrate efficacy of the concept in vivo. The agent will be tested on tumor models and on spontaneous tumors in dogs and cats. Following optimization of particles methodology will be developed to assess various types of cancer using a mouse model. The intent of the technology is to detect small tumors when the possibility of cure is greatest.