DRUG USAGE EVALUATION & INTERVENTION IN AIDS POPULATION

我研究的这一阶段将开发和测试一个微型计算机程序 旨在改善正在进行的治疗的药物使用评估(应) 在艾滋病人群中对抗艾滋病毒和机会性病原体。到期 是一项基本的质量保证活动，但80%到88%的 医院没有有效地将应有的纳入他们的质量中 保证计划。这项第一阶段研究将通过以下方式解决这一问题 开发一种交互式计算机程序，使用户可以随时 药剂师对包含适当DUE的药物数据库的访问 艾滋病患者管理标准。该程序将收到 输入患者特征和疾病、药物、治疗和肾脏 功能信息。基于访问药物的子例程 数据库、药代动力学剂量软件和医院应有的标准 对于艾滋病治疗，方案输出将建议修改 治疗(如果需要)，并通知卫生保健专业人员 建议或修改的治疗方案可能存在的问题。 该程序的测试将评估该程序的准确性 推荐，使用医院药房的应有评价和 治疗(P&T)委员会被评为“黄金标准”。最后，由于一个 新入院的艾滋病患者人数将使用应有的 程序。方案的建议与P的建议一致 将对&T委员会进行评估。

This phase I study would develop and test a microcomputer program intended to improve the drug usage evaluation (DUE) for therapies active against the HIV and opportunistic pathogens in the AIDS population. DUE is an essential quality assurance activity, but 80 to 88% of all hospitals have not effectively incorporated DUE into their quality assurance program. This Phase I study would address this problem through development of an interactive computer program which would allow ready access by the pharmacist to a drug database containing proper DUE criteria for the management of AIDS patients. The program would receive input of patient characteristics and disease, drug, therapeutic and renal function information. Based upon subroutines which access a drug database, pharmacokinetic dosing software and the hospital's DUE criteria for AIDS therapy, the program output would recommend modifications in therapy (if needed) and notifying health care professionals of the potential problems with the proposed or modified therapeutic regimen. Tests of the program would evaluate the accuracy of the program's recommendation, using the DUE evaluation of the hospital pharmacy and therapeutics (P & T) Committee as the "Gold Standard." Finally, DUE of a population of newly admitted AIDS patients would be done using the DUE program. Concurrence of the program's recommendation with that of the P & T Committee would be evaluated.