MASS SPECTROMETRIC SURFACE ANALYSIS OF MEMBRANES

膜的质谱表面分析

• 批准号: 3498797
• 负责人: Constance M John
• 金额: $ 4.99万
• 依托单位: CHARLES EVANS AND ASSOCIATES
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-15 至 1992-10-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3498797
• 关键词: chemical binding; intermolecular interaction; ionizing radiation; ions; mass spectrometry; membrane model; membrane structure; method development; surface property

DESCRIPTION (Adapted from Applicant's Abstract):The Phase I research will evaluate the feasibility of using time-of-flight secondary ion mass spectrometry (TOF-SIMS) to provide sensitive and structurally significant characterization of the surface composition of biological membranes. The research will analyze a variety of model membrane systems in order to fully evaluate this feasibility. The data produced in this study will be evaluated specifically with regard to its diagnostic value in elucidation membrane chemical structure. The long term objective of this research is to develop routine, quantitative surface analysis techniques for the chemical analysis of membrane surfaces. The achievement of this objective could find extensive application in a variety of biological sciences including synthetic membrane development, fundamental investigations of membrane structure/function relationships and possibly, better understanding of the role biomembranes play in the state of health of organisms.

描述(改编自申请者摘要)：第一阶段研究将 评价利用飞行时间二次离子质量的可行性 光谱(TOF-SIMS)提供灵敏的和具有结构意义的 生物膜表面组成的表征。这个 研究人员将对各种模型膜系统进行分析，以便充分 评估这一可行性。这项研究中产生的数据将是 就其在阐明中的诊断价值进行专门评估 膜化学结构。 这项研究的长期目标是制定常规， 化学分析中的定量表面分析技术 膜表面。这一目标的实现可以得到广泛的 在各种生物科学中的应用，包括合成 膜的发展、膜的基础研究 结构/功能关系，并可能更好地理解 生物膜在生物体的健康状态中发挥作用。