DEVELOPMENT OF A NOVEL TTS--MEMBRANE OPTIMIZATION

新型 TTS 的开发——膜优化

• 批准号: 3498522
• 负责人: EDWARD E SCHMITT
• 金额: $ 5万
• 依托单位: LANDEC CORPORATION
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-02-01 至 1992-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3498522
• 关键词: bioengineering /biomedical engineering; diffusion; drug delivery systems; membrane; membrane permeability; method development; polymers; skin; slow release drug; temperature; topical drug application

DESCRIPTION: (Adapted from the Applicant's Abstract). This proposal describes the chemical development of a novel pulsed transdermal therapeutic system (TTS) using existing and conceptualized Intelimer TM polymeric membranes proprietary to Landec Labs. Ultimately, the system will enable pulsed, ramp, and diurnal dosing regimens. Potential benefits derived from such a system include the reduction of tolerance, improved patient compliance, and patient controlled therapy. The heart of the pulsed transdermal system is the Intelimer TM class of polymeric controlled release materials. These polymers have a very low permeability to a variety of drugs below a "switch temperature' and a very high permeability above that temperature. The work to be performed in this research proposal will focus on optimizing these polymers and the membranes prepared from them. The flux of selected model drug compounds through the membranes will be measured as a function of temperature.Diffusion parameters will be computed and these results will be used to modify and optimize the polymer materials to achieve the desired "switch temperature" and release rate. Finally, laminating techniques will be established and in vitro release profiles of the laminated device will be measured.

描述：（改编自申请人的摘要）。 这个提议 描述了新型脉冲透皮药物的化学开发 使用现有和概念化的 Intelimer TM 的治疗系统 (TTS) Landec Labs 专有的聚合物膜。最终，系统将 启用脉冲、斜坡和每日给药方案。 潜在的好处 源自这样一个系统的包括减少耐受性、改进 患者依从性和患者控制治疗。 脉冲透皮系统的核心是 Intelimer TM 类 聚合物控释材料。 这些聚合物具有非常低的 在“转换温度”以下对多种药物的渗透性和非常 高于该温度时具有高渗透性。 本次要开展的工作 研究计划将侧重于优化这些聚合物和膜 从他们那里准备的。 所选模型药物化合物通过的通量 膜将作为温度的函数进行测量。扩散 将计算参数，这些结果将用于修改和 优化聚合物材料以达到所需的“切换温度” 和释放率。 最后，将建立层压技术并 将测量层压装置的体外释放曲线。