ALEXANDRITE LASER FOR PDT CANCER RESEARCH

用于 PDT 癌症研究的亚历山大石激光器

• 批准号: 3491853
• 负责人: JOHN C WALLING
• 金额: $ 5万
• 依托单位: LIGHT AGE, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-05-15 至 1988-11-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3491853
• 关键词: biomedical equipment resource; clinical biomedical equipment; lasers; neoplasm /cancer therapy; radiosensitizer

Our objectives is to develop a more effective approach to photodynamic therapy (PDT) of cancer by combining two emergent technologies: a) New photosensitizers with improved photochemical characteristics which operate in the deep red wavelength region where body tissue is most translucent, and b) The alexandrite laser1, a superior wavelength tunable solid state laser source in this spectral region. Included among these new photosensitizers are verdins2, purpurins3, bacteriochlorin4, silicon naphthalocyanine5,6,7 and bacteriopheophorbide8, with peak absorption, respectively, at xxxx, 715nm, 765nm, and 755nm. While an emergent technology, laboratory alexandrite lasers, continuously tunable from 710nm to over 800nm in pulsed mode and 740nm to 800nm is continuous mode, have demonstrated performance will within application requirements, and are well adapted to fiber optic delivery. The objectives of this first phase are the construction of a suitably configured alexandrite laser for PDT experimentation, and the test and evaluation of this laser with the verdins and other appropriate photosensitizers using laboratory rats by established methods. The results will guide further development of the laser, beam delivery apparatus and treatment protocol, leading, potentially, to a cost effective clinical laser for PDT.

我们的目标是开发一种更有效的方法 结合两种方法治疗癌症的光动力疗法 (PDT) 新兴技术：a) 改进的新型光敏剂 在深红色中起作用的光化学特性 身体组织最透明的波长区域，b) 紫翠玉激光器1，一种卓越的波长可调谐固态 在此光谱区域的激光源。 包括在这些新 光敏剂有 verdins2、红紫素3、菌绿素4、硅 萘酞菁5,6,7 和细菌脱镁叶绿酸8，有峰 分别在 xxxx、715nm、765nm 和 755nm 处吸收。 虽然实验室紫翠玉激光器是一项新兴技术， 在脉冲模式下从 710nm 连续可调到 800nm 以上 并且740nm至800nm是连续模式，已经证明 性能将在应用程序要求之内，并且很好 适应光纤传输。 第一阶段的目标 是一个适当配置的紫翠玉激光器的构造 PDT实验以及该激光器的测试和评估 与 verdins 和其他适当的光敏剂一起使用 通过既定方法进行实验大鼠。 结果将指导 进一步开发激光器、光束传输装置和 治疗方案，可能会带来成本效益 用于 PDT 的临床激光。