ALEXANDRITE LASER FOR PDT CANCER RESEARCH

我们的目标是开发一种更有效的方法来 光动力疗法(PDT)联合治疗癌症 新兴技术：a)经过改进的新型光敏剂 在深红色中工作的光化学特性 身体组织最透明的波长区域，以及b) 紫翠宝石激光器1，一种卓越的波长可调固态 这一光谱区域的激光光源。包括在这些新的 光敏剂有verdins2、紫红素3、细菌素4、硅 5，6，7和细菌邻位联碱8，具有峰 分别在xxxx、715 nm、765 nm和755 nm处有吸收。 而一项新兴技术，实验室翠绿宝石激光器， 脉冲模式下从710 nm到800 nm以上连续可调 以及740 Nm至800 Nm为连续模式，已演示 性能将符合应用程序要求，并且性能良好 适用于光纤传输。第一阶段的目标是 是否构造了适当配置的紫翠宝石激光器用于 PDT实验，以及对该激光器的测试和评价 利用马鞭草和其他适当的光敏剂使用 通过已建立的方法进行实验。其结果将指导 进一步发展激光、光束传输装置和 治疗方案，潜在地导致成本效益 临床激光治疗光动力疗法。

Our objectives is to develop a more effective approach to photodynamic therapy (PDT) of cancer by combining two emergent technologies: a) New photosensitizers with improved photochemical characteristics which operate in the deep red wavelength region where body tissue is most translucent, and b) The alexandrite laser1, a superior wavelength tunable solid state laser source in this spectral region. Included among these new photosensitizers are verdins2, purpurins3, bacteriochlorin4, silicon naphthalocyanine5,6,7 and bacteriopheophorbide8, with peak absorption, respectively, at xxxx, 715nm, 765nm, and 755nm. While an emergent technology, laboratory alexandrite lasers, continuously tunable from 710nm to over 800nm in pulsed mode and 740nm to 800nm is continuous mode, have demonstrated performance will within application requirements, and are well adapted to fiber optic delivery. The objectives of this first phase are the construction of a suitably configured alexandrite laser for PDT experimentation, and the test and evaluation of this laser with the verdins and other appropriate photosensitizers using laboratory rats by established methods. The results will guide further development of the laser, beam delivery apparatus and treatment protocol, leading, potentially, to a cost effective clinical laser for PDT.