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PICOLITER LASER-BASED ABSORBANCE AND RI DETECTOR

PICOLITER LASER-BASED ABSORBANCE AND RI DETECTOR
皮升激光吸光度和 RI 检测器
批准号:
3498108
负责人:
DARRYL J. BORNHOP
金额:
$4.99万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-05-01 至 1988-11-30

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项目成果

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中文摘要
翻译
毛细管分离技术对样品有严格的要求
英文摘要
Capillary separation techniques place stringent requirements on chromatographic detection systems. Detectors for separation techniques, such as capillary liquid chromatography, capillary supercritical fluid chromatography, and capillary zone electrophoresis, are required to measure minute amounts of the analytes. Detectors must have sub-nanoliter cell volumes to avoid efficiency and resolution loss due to solute band-broadening. Currently, low volume detectors that have high sensitivity and retain the integrity of the highly efficient separation are not commercially available. Thermo-optical absorbance measurements can be used to make very sensitive absorbance determinations within picoliter volume cells. The proposed research will develop on thermo-optical absorbance technique for detection in capillary chromatography. In Phase I, the feasibility of the picoliter laser-based absorbance/refractive index (RI) detector for highly sensitive low volume analyte detection in capillary based flowing systems will be investigated. In Phase II, the detector will be interfaced to capillary chromatographic systems for performance evaluations of the integrated system for analyses aimed at elucidating biomolecular and cellular structure and function. The overall goal of the proposal is to develop a commercial picoliter volume, thermo-optical detector for capillary chromatographic systems.
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Translation of Interferometric-based Free-solution Assay Methodology
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