NATURAL PRODUCT DRUG FROM STRESSED MARINE INVERTEBRATE

该项目的目标是开发方法， 海洋生物活性化合物合成 生物，并测试这些“标签代谢物”（=化感物质）， 抗肿瘤活性。这些方法旨在确定潜在的 用于在特定的底栖生态系统内产生“标记代谢物”， 纳入正在进行的海洋生物系统采集 提高生产力的计划。的下列 无脊椎动物门将用于生态压力实验： 多孔动物（海绵），珊瑚虫（珊瑚），苔藓虫（外肛），和 尾索动物（被囊动物）。第一阶段将制定生态协议， 胁迫结壳海洋无脊椎动物产生“标记代谢物”。相 我们将把这些努力扩大到其他地理区域， 通过田间试验的实验室培养应用调查 利用那些能产生非常有趣的 化合物;主要候选物将获得专利并授权给政府 或者制药公司来帮助她的发展预计各国 在靶向治疗组中具有活性的“标记代谢物”将被 制药工业感兴趣的新化合物。

The goal of this project is to develop methods that cause the de novo synthesis of biologically active aIlelochemicals by encrusting marine organisms, and to test these "tag metabolites" (=allelochemicals) for antitumor activity. These methods are designed to determine the potential for "tag metabolite" production within a given benthic ecosystem, and can be incorporated into on-going systematic marine organism acquisition programs to enhance productivity. Representatives of the following invertebrate Phyla will be used in the ecological stress experiments: Porifera (sponges), Criidaria (corals), Bryozoa (ectoprocts), and Urochordata (tunicates). Phase I will develop protocols that ecologically stress encrusting marine invertebrates to produce "tag metabolites". Phase ll will expand these efforts to other geographic regions, and further the investigation by laboratory culture application of the field experiments using those organisms that produce pharmacologically interesting compounds; lead candidates will be patented and licensed to the government or to pharmaceutical companies for her development. It is anticipated that "tag metabolites" with activity in the target therapeutic groups will be novel compounds of interest to the pharmaceutical industry.