AUTOMATED BISENSORS OPERATED UNDER TRANSIENT MODE

这项研究的总体目标是开发一种可靠和 灵敏的单、多个二维膜氧电极 该系统是一种潜在的化疗药物筛选系统。 PBI开发这种溶解气体测量系统的方法是 建立在现有膜电极设计的基础上，并使用微型计算机 还有一个内部开发的软件来解决一些问题 与传统的膜电极技术相关联。 这种非侵入性技术可用于细胞培养监测 细胞基础代谢影响因素的研究 代谢，以及细胞毒性引起的细胞变化的研究 化合物、激素和其他具有药理活性的药物。这可以 也可用于检测各种化学物质的毒性和安全性 食品中使用的助剂。可应用于临床环境中的检测 不同的药物组合和其他化疗药物的组合 养生法。这项技术的体外和体内应用也可以 扩展到生物医学领域，例如监测血糖、二氧化碳、 血等。

The overall objective of this research is to develop a reliable and sensitive single and multiple two-dimensional membrane oxygen electrode system as a potential screening system for chemotherapeutic agents. PBI's approach to developing this dissolved-gas measurement system is to build on an existing membrane electrode design and to use a microcomputer and an in-house developed software to overcome some of the problems associated with traditional membrane electrode technology. This non-invasive technology can be used in cell culture monitoring in studies on basic cellular metabolism on factors affecting this metabolism, and in studies on cellular changes due to cytotoxic compounds, hormones, and other pharmacologically active drugs. This can also be used to examine the toxicity and safety of various chemical agents used in food. It can be applied in clinical settings in testing different drug combinations and other combinations of of chemotherapeutic regimen. In-vitro and in-vivo applications of this technology can also be extended to the biomedical area, e.g. monitoring glucose, pCO2, in blood , etc.