ALCOHOL MEASUREMENTS FOR TREATMENT COMPLIANCE

建议研究的长远目标，是制订一套 基于水合固体的微型电化学检测器 用于经皮酒精测量的聚合物电解质 治疗依从性。第二阶段提案的具体目标是 1)优化传感器单元扩散控制和电子 控制/记录功能，2）开发可穿戴的被动原型 传感器/记录器设备，以及3）实施协议以评估 用于经皮监测重要疾病的先进原型设备 临床试验中的受试者数量。方法是确定 用于传感器单元的速率限制膜20形成有效的低 电流和敏感电子电路，3）开发小型化固体 状态记录器，以及40将组件封装成单元化原型 在透皮酒精研究中由人类受试者佩戴的装置， 与罗杰威廉姆斯医院合作进行。拟议 固体聚合物电解质电化学传感器和扩散控制 系统是一个新概念，专门为长期 透皮酒精测量。此外，建议的小型化 微控制器/记录器系统，它存储数据，并给出一个 酒精消费的历史，具有技术潜力， 创新

The long term objective of the proposed study is to develop a miniaturized electrochemical detector, based on the hydrated solid polymer electrolyte for transdermal alcohol measurements to monitor treatment compliance. The specific aims of this Phase II proposal are to 1) optimize the sensor cell diffusion control and electronic control/recorder functions, 2) develop wearable, passive prototype sensor/recorder devices, and 3) implement a protocol to evaluate the advanced prototype devices for transdermal monitoring of a significant number of subjects in clinical testing. The methodology is to 10 identify a rate limiting membrane for the sensor cell, 20 develop an efficient low current and sensitive electronic circuit, 3) develop a miniaturized solid state recorder, and 40 package the components into a unitized prototype device to be worn by human subjects in transdermal alcohol studies, conducted in collaboration with Roger Williams Hospital. The proposed solid polymer electrolyte electrochemical sensor and diffusion control system are a novel concept, specifically designed for long term transdermal alcohol measurements. Also, the proposed miniaturized microcontroller/recorder system, which stores data and gives an historical of alcohol consumption, has potential for technical innovation.