ALCOHOL MEASUREMENTS FOR TREATMENT COMPLIANCE

用于治疗依从性的酒精测量

• 批准号: 3505720
• 负责人: LARRY L SWETTE
• 金额: $ 18.85万
• 依托单位: GINER, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-29 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3505720
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; breath tests; clinical biomedical equipment; electrochemistry; electronic recording system; human subject; patient monitoring device; skin; therapy compliance

The long term objective of the proposed study is to develop a miniaturized electrochemical detector, based on the hydrated solid polymer electrolyte for transdermal alcohol measurements to monitor treatment compliance. The specific aims of this Phase II proposal are to 1) optimize the sensor cell diffusion control and electronic control/recorder functions, 2) develop wearable, passive prototype sensor/recorder devices, and 3) implement a protocol to evaluate the advanced prototype devices for transdermal monitoring of a significant number of subjects in clinical testing. The methodology is to 10 identify a rate limiting membrane for the sensor cell, 20 develop an efficient low current and sensitive electronic circuit, 3) develop a miniaturized solid state recorder, and 40 package the components into a unitized prototype device to be worn by human subjects in transdermal alcohol studies, conducted in collaboration with Roger Williams Hospital. The proposed solid polymer electrolyte electrochemical sensor and diffusion control system are a novel concept, specifically designed for long term transdermal alcohol measurements. Also, the proposed miniaturized microcontroller/recorder system, which stores data and gives an historical of alcohol consumption, has potential for technical innovation.

拟议研究的长期目标是制定一项 基于水合固体的微型电化学检测器 用于监测酒精透皮测量的聚合物电解质 治疗依从性。这项第二阶段提案的具体目标是 1)优化传感器单元扩散控制和电子 控制/录像机功能，2)开发可穿戴的被动原型 传感器/记录器设备，以及3)实施协议以评估 先进的原型设备用于透皮监测的重要意义 临床试验的受试者数量。方法论是确定10个 一种用于传感器单元的限速膜，20形成一种高效的低 电流灵敏电子电路；3)研制小型化固体 状态记录器，并将组件打包成单元化的原型 人体受试者在透皮酒精研究中佩戴的装置， 与罗杰·威廉姆斯医院合作进行。建议数 固体聚合物电解质电化学传感器及其扩散控制 系统是一个新概念，专门为长期设计 酒精透皮测量。此外，建议的小型化 微控制器/记录器系统，它存储数据并提供 有饮酒历史，具有技术潜力 创新。