UNHEATED TRANSCUTANEOUS PCO2 SENSOR FOR NEONATES

该计划的总体目标是开发一种先进的 用于经皮测量CO2的电化学传感器， 特别适用于新生儿。 传感器会很精确， 可靠、安全、易于使用，设计为在正常身体附近操作 温度 第一阶段计划的具体目标是扩大， 通过先进的传感器单元开发，获得专利的Giner，Inc. 经皮（P（tc）CO2）的电化学pCO2传感器概念 测量和演示可行的操作在37摄氏度使用 体外和动物试验。 方法将是测试先进的 新生仔猪上的传感器配置，以证明概念 可行性，并将37 ℃时的P（tc）CO2与动脉CO2相关联 （p[a]CO2）测量。 技术上有很大的潜力。 创新 所提出的p（tc）CO2传感器将具有若干优点 新生儿应用的最新技术：1）37岁手术 摄氏度将消除在44摄氏度发生的烧伤，2）信号 是pCO2的直接函数，而不是对数pH响应， 将提供更灵敏和可靠的信号，以及3）传感器将 比Severinghaus型更坚固（没有玻璃）和不变 传感器. 在第二阶段，先进的原型仪器具有独特的 将开发P（tc）CO2传感器单元并扩展测量 到成年人，最终到新生儿。

The overall goal of the proposed program is to develop an advanced electrochemical sensor for transcutaneous measurements of CO2 that is specifically applicable to neonates. The sensor will be accurate, reliable, safe, easy to use and designed to operate near normal body temperature. The specific aims of this Phase I program are to extend, through advanced sensor cell development, the patented Giner, Inc. electrochemical pCO2 sensor concept to transcutaneous (P(tc)CO2) measurement and demonstrate viable operation at 37 degrees C using in vitro and animal testing. The approach will be to test the advanced sensor configuration on newborn piglets to demonstrate concept feasibility and correlate P(tc)CO2 at 37 degrees C to arterial CO2 (p[a]CO2)measurements. There is significant potential for technological innovation. The proposed p(tc)CO2 sensor would have several advantages over current technology for neonatal application: 1) operation at 37 degrees C would eliminate burns that occur at 44 degrees C, 2) the signal is a direct function of pCO2 rather than a logarithmic pH response and will provide a more sensitive and reliable signal, and 3) the sensor will be more rugged (no glass) and invariant than the Severinghaus-type sensor. In Phase II an advanced prototype instrument with the unique P(tc)CO2 sensor cell will be developed and measurements will be extended to adults and, ultimately, neonates.