课题基金 / 基金详情

UNHEATED TRANSCUTANEOUS PCO2 SENSOR FOR NEONATES

UNHEATED TRANSCUTANEOUS PCO2 SENSOR FOR NEONATES
适用于新生儿的未加热经皮 PCO2 传感器
批准号:
3499901
负责人:
LARRY L SWETTE
金额:
$5.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1991
资助国家:
美国
项目状态:
已结题
起止时间:
1991-09-30 至 1992-07-31

项目摘要

项目成果

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中文摘要
翻译
拟议计划的总体目标是开发一种先进的 用于经皮测量二氧化碳的电化学传感器,即 特别适用于新生儿。传感器将是准确的, 可靠,安全,易于使用,设计为接近正常身体操作 温度。这一阶段计划的具体目标是扩大, 通过先进的传感器单元开发,获得专利的Giner,Inc. 经皮(P(TC)CO2)电化学二氧化碳传感器概念 使用中测量并演示在37摄氏度下可行的操作 体外和动物试验。方法将是测试先进的 新生仔猪的传感器配置以演示概念 37℃时P(TC)CO_2的可行性及其与动脉CO_2的相关性 (P[a]二氧化碳)测量。技术上有巨大的潜力 创新。提出的p(Tc)co2传感器有几个优点。 过流的新生儿应用技术:1)37岁时手术 摄氏度将消除44摄氏度时发生的灼伤,2)信号 是二氧化碳的直接函数,而不是对数的pH响应 将提供更灵敏和可靠的信号,以及3)传感器将 比Severinghaus类型的更坚固(没有玻璃)和不变性 传感器。在第二阶段,一个先进的原型仪器,具有独特的 将开发P(TC)二氧化碳传感器单元,并扩大测量范围 对成年人,并最终对新生儿。
英文摘要
The overall goal of the proposed program is to develop an advanced electrochemical sensor for transcutaneous measurements of CO2 that is specifically applicable to neonates. The sensor will be accurate, reliable, safe, easy to use and designed to operate near normal body temperature. The specific aims of this Phase I program are to extend, through advanced sensor cell development, the patented Giner, Inc. electrochemical pCO2 sensor concept to transcutaneous (P(tc)CO2) measurement and demonstrate viable operation at 37 degrees C using in vitro and animal testing. The approach will be to test the advanced sensor configuration on newborn piglets to demonstrate concept feasibility and correlate P(tc)CO2 at 37 degrees C to arterial CO2 (p[a]CO2)measurements. There is significant potential for technological innovation. The proposed p(tc)CO2 sensor would have several advantages over current technology for neonatal application: 1) operation at 37 degrees C would eliminate burns that occur at 44 degrees C, 2) the signal is a direct function of pCO2 rather than a logarithmic pH response and will provide a more sensitive and reliable signal, and 3) the sensor will be more rugged (no glass) and invariant than the Severinghaus-type sensor. In Phase II an advanced prototype instrument with the unique P(tc)CO2 sensor cell will be developed and measurements will be extended to adults and, ultimately, neonates.
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MINIATURIZED WEARABLE TRANSDERMAL ALCOHOL MONITOR
  • 批准号:
    6157681
  • 项目类别:
  • 资助金额:
    $74.82万
  • 财政年份:
    1999
  • 负责人:
    LARRY L SWETTE
  • 依托单位:
MINIATURIZED WEARABLE TRANSDERMAL ALCOHOL MONITOR
  • 批准号:
    6359338
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    1999
  • 负责人:
    LARRY L SWETTE
  • 依托单位:
MINIATURIZED WEARABLE TRANSDERMAL ALCOHOL MONITOR
  • 批准号:
    6097532
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    1998
  • 负责人:
    LARRY L SWETTE
  • 依托单位:
MINIATURIZED WEARABLE TRANSDERMAL ALCOHOL MONITOR
  • 批准号:
    2879397
  • 项目类别:
  • 资助金额:
    $9.12万
  • 财政年份:
    1998
  • 负责人:
    LARRY L SWETTE
  • 依托单位:
海外基金