TRANSIENT GAS SENSORS

瞬态气体传感器

• 批准号: 3501305
• 负责人: PHILIP LESSNER
• 金额: $ 5万
• 依托单位: GINER, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1990-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3501305
• 关键词: biosensor device; clinical biomedical equipment; electrical measurement; electrodes; oxygen tension; respiratory gas analyzer

The conventional Clark type oxygen sensor needs frequent recalibration when implanted in vivo due to membrane fouling, electrolyte thickness changes due to pressure variations, and the fluctuating flow rate of blood. An improved oxygen sensor is proposed (which is a modified Clark sensor) which reduces or eliminates many of those problems. The proposed sensor uses the following approaches: 1) a measuring pulse based on the establishment of a transient diffusional concentration gradient, 2) an electrical waveform for in situ conditioning (reactivating) of the sensor electrode, 3) all noble metal, non- contaminating electrodes in a non-chloride, acidic electrolyte, and 4) sensing electrode geometries which enhance the signal to noise ratio. During Phase I the optimum material and electrical parameters will be chosen based exclusively on in vitro laboratory testing of a macrosensor. Work during Phase II will concentrate on translating this technology into an implantable sensor for blood and/or tissue oxygen measurements and on carrying out an extensive in vivo testing program aimed at verifying the approach and at optimization of the sensor.

传统的克拉克型氧传感器需要频繁重新校准 当植入体内时，由于膜污染、电解质厚度 由于压力变化和流量波动而变化 血。 提出了一种改进的氧传感器（这是一种改进的Clark 传感器），这减少或消除了许多这样的问题。 这 建议的传感器采用以下方法：1) 测量脉冲 基于瞬时扩散浓度的建立 梯度，2) 用于原位调节的电波形 （重新激活）传感器电极，3）所有贵金属，非 非氯化物酸性电解质中污染电极，以及 4) 提高信噪比的传感电极几何形状。 在第一阶段，最佳材料和电气参数将是 仅根据体外实验室测试选择 宏观传感器。 第二阶段的工作将集中于翻译此 技术融入可植入血液和/或组织氧传感器 测量并进行广泛的体内测试计划 旨在验证该方法并优化传感器。