IMPROVED CONTRACEPTIVE DRUG DELIVERY SYSTEM

改进的避孕药物输送系统

• 批准号: 3499438
• 负责人: JOY HOCHSTADT
• 金额: $ 4.78万
• 依托单位: HERCON LABORATORIES CORPORATION
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-01 至 1989-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3499438
• 关键词: drug administration rate /duration; drug administration routes; drug delivery systems; female antifertility drug; pharmacokinetics; skin

The Hercon Laboratories proposes to develop a simple, inexpensive patch that will transdermally deliver contraceptive drug to patients. The patch will utilize Hercon's patented multilayer polymeric dispenser of drugs, which consists of a reservoir layer containing the drug sealed between outer layers. A pressure-sensitive adhesive holds the patch onto the skin, the outermost layer is impervious, forcing the drug to diffuse toward the skin. Rate of drug delivery is controlled by the layer next to the skin. Advantages of the patch are constant drug delivery over prolonged periods at the therapeutic level, elimination of many side effects, greater drug bioavailability then with oral drugs, greater patient compliance, and more safety than with other dosage forms. Hercon is uniquely qualified to develop the desired product and do so efficiently. It has been a leader in the field of controlled-release technology for more than a decade. Its staff has specialized experience and knowledge in formulation pharmaceuticals, skin-care products, and toiletries as well as research experience and in-depth knowledge on transdermal delivery of drugs. These capabilities are supported by a research oriented management, a dedicated technical and engineering staff, and a multi-million dollar manufacturing facility.

Hercon实验室提议开发一种简单、廉价的补丁 这将通过经皮给患者输送避孕药。补丁 将使用赫康专利的多层聚合物药物分配器， 其由包含密封在其间的药物的储存层组成 外层。一种压敏粘合剂将贴片固定在 皮肤，最外层是不透水的，迫使药物扩散 朝向皮肤。药物递送速度由旁边的层控制 皮肤。 这种贴剂的优点是长时间持续给药。 在治疗层面上，消除了许多副作用，更大的药物 口服药物的生物利用度，更好的患者依从性，以及 比其他剂型更安全。 Hercon是唯一有资格开发所需产品并这样做的人 效率很高。它在控制释放领域一直处于领先地位 技术已经有十多年了。它的工作人员有专门的经验 以及配方药物、护肤品和 洗漱用品以及研究经验和深入了解 药物经皮给药。这些功能由 以研究为导向的管理，一种专注的技术和工程 员工，以及一个价值数百万美元的制造设施。