SEGMENTAL PULSATILE PRESSURE CUFF/ANALYZER DEVELOPMENT

拟议的研究将开发准确的节段性脉搏压力 (SPP)分析仪和阴茎节段性袖带检测阴茎血流 和压力脉冲。目标是构建两个用于研究的原型 以及对男性阳萎的评估。 卡拉坎博士之前关于男性阳萎的研究表明，提议的 该装置可以用来检测和评估阴茎的脉搏。他的作品 已经表明，这样的袖带不能导致阴茎的身体畸形 在评估过程中，分析仪应该是准确的，并能够 保持袖带充气压力12小时，不超过5% 下垂。早期的调查是用特制的手铐进行的 用于检测四肢动脉阻塞；该仪器(脉搏体积 录音机，由生命科学公司制造。)可以维持袖口通胀 压力只有30分钟。Balkanli博士对该仪器进行了改进 并提供了具体应用和工程咨询及两个 本申请中引用的原型。临床应用将包括 评价正常男性和高血压男性的勃起血流动力学。 巴尔坎利博士将授权德克萨斯医疗电子公司使用美国专利 #4,279,155(波登管换能器)，用于开发两种分析仪 原型。

The proposed study will develop an accurate segmental pulsatile pressure (SPP) analyzer and penile segmental cuff for detecting penile blood flow and pressure pulses. The goal is to construct two prototypes for studying and evaluating male impotence. Dr. Karacan's previous work on male impotence has shown that the proposed device could be used to detect and evaluate penile blood pulses. His work has shown that such a cuff must not cause physical deformity of penis during evaluation, and that the analyzer should be accurate and capable of maintaining cuff inflation pressure for 12 hours with no more than 5% droop. Early investigations were conducted with a cuff specially developed for detecting arterial blockage in limbs; the instrument (Pulse Volume Recorder, manufactured by Life Science, Inc.) could maintain cuff inflation pressure for only 30 minutes. Dr. Balkanli modified that instrument for the specific application and provided engineering consultation and two prototypes cited in this application. Clinical application will consist of evaluation erectile hemodynamics in normal and hypertensive males. Dr. Balkanli will license Texas Medical Electronics Co. to use U.S. Patent #4,279,155 (a bourdon tube transducer) for developing the two analyzer prototypes.