EFFECT OF ASTHMACEDAR ON ASTHMATIC ANIMALS

该补助金的目的是确定负责的活性成分 在红雪松的树脂中发现了一种抗哮喘的活性， 树 在古巴农村，雪松被用作抗哮喘的民间疗法 在Rene M博士之前的几代人中，古巴医生莫拉开始 使用树脂制剂，取得了显著的成功。 轶事数据 本报告中提供的信息现在得到了初步调查结果的证实。 在两种动物模型中进行实验。 在蛔虫敏感的羊中， 在特定的肺阻力中，人们通常观察到响应于 气溶胶A.通过一个五周的治疗， 气喘药 在卵清蛋白致敏的豚鼠中， 由于抗原暴露而引起的免疫缺陷通过饲喂雪松 树脂的豚鼠几个星期，并通过直接孵育的 用准备好的纸条。 在豚鼠体内，雪松树脂 似乎不是抗组胺剂或抗白三烯剂，而是 通过另一种机制。 没有人或动物受试者 服用过这种药物的人都没有出现任何毒性症状 体外豚鼠生物测定的相对速度和经济性使得 提出了压裂鉴定活性组分的可行性建议， 雪松树脂

The objective of this grant is to identify the active principle responsible for an anti-asthmatic activity discovered in the resin of the red cedar tree. Cedar had been used as an anti-asthmatic folk remedy in rural Cuba for many generations before Dr. Rene M. Mora, a Cuban physician, began using the resin preparation with remarkable success. The anecdotal data offered in this report are now corroborated by results of preliminary experiments in two animal models. In Ascaris-sensitive sheep, the increase in specific lung resistance that one normally observes in response to an aerosol of A. suum is reduced significantly by one five-week treatment with Asthmacedar. In ovalbumin-sensitized guinea pigs, the contractive response resulting from antigen exposure is mitigated both by the feeding of cedar resin to the guinea pigs for several weeks and by direct incubation of the strips with the preparation. In the guinea pig system, the cedar resin appears not to be an anti-histamine or anti-leukotriene, but rather to be acting through another mechanism. None of the human or animal subjects to whom this drug has been administered have revealed any signs of toxicity. The relative speed and economy of the in vitro guinea pig bioassay makes feasible the proposal to fractionate and identify the active component in the cedar resin.