EFFECT OF ASTHMACEDAR ON ASTHMATIC ANIMALS

Asthmacedar 对哮喘动物的影响

• 批准号: 3500571
• 负责人: ALBERT E DAHLBERG
• 金额: $ 4.11万
• 依托单位: MORA AND DAHLBERG PHARMACEUTICALS, INC.
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-04-01 至 1985-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3500571
• 关键词: antiallergic agents; asthma; bioassay; biological products; disease /disorder model; drug design /synthesis /production; drug metabolism; expectorant /mucolytic; folk medicine; high performance liquid chromatography; medicinal plants; plant extracts; plants; resin; respiratory disorder chemotherapy; ultracentrifugation

The objective of this grant is to identify the active principle responsible for an anti-asthmatic activity discovered in the resin of the red cedar tree. Cedar had been used as an anti-asthmatic folk remedy in rural Cuba for many generations before Dr. Rene M. Mora, a Cuban physician, began using the resin preparation with remarkable success. The anecdotal data offered in this report are now corroborated by results of preliminary experiments in two animal models. In Ascaris-sensitive sheep, the increase in specific lung resistance that one normally observes in response to an aerosol of A. suum is reduced significantly by one five-week treatment with Asthmacedar. In ovalbumin-sensitized guinea pigs, the contractive response resulting from antigen exposure is mitigated both by the feeding of cedar resin to the guinea pigs for several weeks and by direct incubation of the strips with the preparation. In the guinea pig system, the cedar resin appears not to be an anti-histamine or anti-leukotriene, but rather to be acting through another mechanism. None of the human or animal subjects to whom this drug has been administered have revealed any signs of toxicity. The relative speed and economy of the in vitro guinea pig bioassay makes feasible the proposal to fractionate and identify the active component in the cedar resin.

这笔赠款的目的是确定负责的主动原则 红雪松树脂中发现的抗哮喘活性 树。 雪松在古巴农村曾被用作抗哮喘的民间疗法 古巴医生雷内·M·莫拉 (Rene M. Mora) 医生开始治疗之前的许多代人 使用该树脂制剂取得了显着的成功。 轶事数据 本报告中提供的内容现已得到初步结果的证实 在两种动物模型中进行实验。 在对蛔虫敏感的绵羊中， 在特定的肺阻力中，人们通常观察到一种反应 经过五周的治疗后，A. suum 的气溶胶显着减少 哮喘雪松。 在卵清蛋白致敏的豚鼠中，收缩反应 饲喂雪松可以减轻因抗原暴露而产生的 将树脂注入豚鼠几周并直接孵化 条带准备。 在豚鼠系统中，雪松树脂 似乎不是抗组胺药或抗白三烯药，而是 通过另一种机制发挥作用。 人类或动物均不会受到 服用该药物的人已显示出任何毒性迹象。 体外豚鼠生物测定的相对速度和经济性使得 分馏和鉴定活性成分的建议是可行的 雪松树脂。