CONTINUOUS DELIVERY RIGHT VENTRICULAR ASSIST SYSTEM

连续输送右心室辅助系统

• 批准号: 3501465
• 负责人: RICHARD K WAMPLER
• 金额: $ 4.72万
• 依托单位: NIMBUS, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1991-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3501465
• 关键词: auxiliary heart prosthesis; clinical biomedical equipment; heart ventricle

[The long-term objectives of the research is to create an implantable temporary right ventricular assist system (RVAS) which is superior to existing devices with respect to size, surgical complexity, ease of use and cost. Approximately 30% of ventricular assist applications involve a RVAS. Current RVAS's are not anatomically compatible with implantability. Yet implantable devices are frequently desirable for longer-term temporary procedures due to their lower potential for infection. An ongoing SBIR Phase II grant (No. 1R43HL40272-02) is directed at providing a left ventricular assist system (LVAS) with the above features. Because it requires much lower pressure rise, the RVAS requires new blade geometry. This Phase I effort will focus on blade geometry development and demonstration through in vitro hydraulic and hemolysis testing and acute in vivo testing. Existing hardware will be utilized. The technical innovation of the subject RVAS concept is that it offers a method of providing effective right heart assistance with a miniature implanted pump that can be placed without the trauma of major surgery.]

[The这项研究的长期目标是创造一种可植入的 临时右心室辅助系统（RVAS），其上级于 现有装置在尺寸、手术复杂性、易用性和 成本 大约30%的心室辅助应用涉及RVAS。 目前的RVAS在解剖学上与植入性不兼容。 然而 可植入装置对于较长期的暂时性、非永久性或非永久性的植入通常是期望的 因为它们感染的可能性较低。 正在进行的SBIR第二阶段赠款（编号1 R43 HL 40272 -02）针对 提供具有上述特征的左心室辅助系统（LVAS）。 因为它需要更低的压力上升，RVAS需要新的叶片 几何 第一阶段的工作重点是叶片几何形状的开发， 通过体外液压和溶血试验以及急性 体内试验 将利用现有硬件。 主题RVAS概念的技术创新在于，它提供了一个 用微型心脏起搏器提供有效的右心辅助的方法 植入式泵，可在没有大手术创伤的情况下放置。