CHRONIC VAS UTILIZING AXIAL FLOW BLOOD PUMP

利用轴流血泵的慢性 VAS

• 批准号: 3501519
• 负责人: RICHARD K WAMPLER
• 金额: $ 4.12万
• 依托单位: NIMBUS, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1991-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3501519
• 关键词: auxiliary heart prosthesis; biomedical equipment development; clinical biomedical equipment

The long-term objective of the proposed activity is to develop, and market an anatomically compatible chronic VAS based on a direct motor driven axial flow blood pump. The specific aim of the Phase I research is to demonstrate the mechanical integrity and blood seal performance together with satisfactory hydraulic and hemolysis performance of the device. The Phase II in vitro and in vivo testing is designed to demonstrate endurance capability, hemolysis, performance and antithrombogenic characteristics through in vitro endurance and chronic in vivo testing. Protocols for Phase I will model those previously developed for the axial flow peripherally introduced Hemopump, which is currently undergoing clinical trials. The technical innovation involves a chronic VAS with a 25cc implantable volume based on demonstrated axial flow blood pumping technology. Other elements of the VAS; the motor, motor controls, percutaneous access and the support pack have a strong technology base in chronic NHLBI VAS research. The commercial potential is based on the small implant volume and lower cost of the VAS compared to conventional cyclic delivery devices.

拟议活动的长期目标是开发和营销 基于直接电机驱动轴的解剖学兼容的慢性 VAS 流动血泵。 第一阶段研究的具体目标是 一起展示机械完整性和血液密封性能 装置具有令人满意的水力和溶血性能。 这 II 期体外和体内测试旨在证明耐力 能力、溶血、性能和抗血栓形成特性 通过体外耐力和长期体内测试。 协议 第一阶段将对先前开发的轴流模型进行建模 外周引进Hemopump，目前正在进行临床 试验。 技术创新涉及带有 25cc 植入式慢性 VAS 基于已证实的轴流血泵技术的体积。 其他 VAS 的要素；电机、电机控制、经皮通路和 支持包在慢性 NHLBI VAS 研究方面拥有强大的技术基础。 商业潜力基于较小的植入物体积和较低的 与传统循环输送装置相比，VAS 的成本。