SURFACE MODIFYING TO IMPROVE URINARY CATHETER FUNCTION

表面修饰以改善导尿管功能

• 批准号: 3495989
• 负责人: DAVID L CLAPPER
• 金额: $ 5万
• 依托单位: SURMODICS, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-06-15 至 1991-03-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3495989
• 关键词: antibacterial agents; bacteriuria; biomaterial interface interaction; ethylene glycols; fluorocarbon polymers; hyaluronate; polymers; silicone rubber; surface property; urinary catheterization

Currently used urinary catheters produce pain upon insertion, injure adjacent tissue, and cause high rates of bacterial infections. These adverse effects are mediated by undesirable surface properties of the catheter polymers. This Phase I project to utilize BSI's proprietary photoimmobilization technology to covalently immobilize reagents expected to both improve the lubricity of catheter surfaces and decrease bacteria colonization. In addition, studies will be initiated to incorporate into the lubricous coating a system that slowly releases antibiotics. The antibiotics should further improve the microbial resistance of the urinary catheter. The two most commonly used types of urinary catheters (latex and silicone) will be coated with reagents that have improved wettability and reduced bacteria colonization when immobilized onto other polymers. Then the coated catheters will be evaluated in vitro for improved wettability, lubricity, and resistance to bacteria colonization. In Phase II, the lubricous and antibiotic coatings will be optimized and evaluated in vitro and in vivo for lubricity, antimicrobial activity, tissue damage, and deposition of encrusting minerals. Since 10% of hospital patients receive urinary catheters, and over 400,000 cases of urinary catheter-associated infections are encountered in the U.S. each year, improved urinary catheters would be extremely beneficial.

目前使用的导尿管在插入时会产生疼痛，损伤 邻近组织，并导致高的细菌感染率。这些 不利的影响是由不受欢迎的表面属性引起的 导管聚合物。该第一阶段项目利用BSI的专有技术 期望采用光固定化技术共价固定化试剂 既能改善导管表面的润滑性，又能减少细菌 殖民主义。此外，将启动研究，将其纳入 这种润滑性的涂层使系统缓慢释放抗生素.这个 抗生素应进一步改善尿路微生物耐药性 导管。 最常用的两种导尿管(乳胶和硅胶) 会涂上一层能改善润湿性和减少 细菌固定在其他聚合物上时的定植。然后是 涂层导管将在体外进行评估，以改善润湿性， 润滑性，耐细菌定植。在第二阶段， 润滑性和抗菌涂层将在体外进行优化和评估 以及体内润滑性、抗菌活性、组织损伤和 结壳矿物的沉积。由于10%的医院患者接受了 导尿管与40多万例导尿管相关 美国每年都会遇到感染，尿路状况有所改善 导尿管将是非常有益的。