OCULAR THERAPEUTIC SYSTEM FOR CONTROLLED DRUG DELIVERY

用于控制药物输送的眼部治疗系统

• 批准号: 3497078
• 负责人: DAVID R GIBSON
• 金额: $ 5万
• 依托单位: MOLECULAR OPHTHALMICS, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-05-04 至 1990-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3497078
• 关键词: biomaterial development /preparation; biomaterial evaluation; contact lens; diffusion; drug delivery systems; eye disorder chemotherapy; membrane permeability; molecular film

It is the objective of this proposal to develop a bandage contact lens or ophthalmic insert which would continuously control the delivery of drug for an extended period of time. These potential products will consist of a hydrogel core containing the dispersed or dissolved therapeutic agent which is encapsulated by a diffusion-limiting barrier membrane coating. The key to the success of the device will be the membrane coating. Langmuir- Blodgett membrane technology is a specialized coating process in which the organic coating is built up by the subsequent additions of monomolecular layers. The coating process is very mild and does not require harsh chemicals or high temperatures. Because the coating thickness can be adjusted with ease and precision and because the mild process will allow the incorporation of labile synthetic and biological drugs, molecular membrane technology will be utilized to develop the proposed ocular drug delivery system.

本提案的目标是开发一种绷带隐形眼镜或